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4  structures 3013  species 0  interactions 3879  sequences 12  architectures

Clan: NfeD-like (CL0252)


NfeD like Add an annotation

This clan includes the NfeD family which contains several proteins described as nodulation efficiency protein D (NfeD). The nfe genes (nfeA, nfeB, and nfeD) are involved in the nodulation efficiency and competitiveness of the Sinorhizobium meliloti strain GR4 on alfalfa roots [1]. The specific function the NfeD family is unknown although it is unlikely that NfeD is specifically involved in nodulation as the family contains several different archaeal and bacterial species most of which are not symbionts.

This clan contains 2 families and the total number of domains in the clan is 3879. The clan was built by J Mistry.

Literature references

  1. Garcia-Rodriguez FM, Toro N; , Mol Plant Microbe Interact 2000;13:583-591.: Sinorhizobium meliloti nfe (nodulation formation efficiency) genes exhibit temporal and spatial expression patterns similar to those of genes involved in symbiotic nitrogen fixation. PUBMED:10830257 EPMC:10830257


This clan contains the following 2 member families:

DUF1449 NfeD

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
NfeD (PF01957) 3628 (93.5%) View
DUF1449 (PF07290) 251 (6.5%) View
Total: 2 Total: 3879 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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