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340  structures 553  species 12  interactions 5385  sequences 136  architectures

Clan: P53-like (CL0073)


Beta-sandwich DNA-binding domain Add an annotation

This clan contains a variety of DNA-binding domains that contain an immunoglobulin-like fold. It includes the DNA-binding domains of NF-kappaB, NFAT, p53, STAT-1, the T-domain and the Runt domain [1].

This clan contains 7 families and the total number of domains in the clan is 5385. The clan was built by A Bateman.

Literature references

  1. Berardi MJ, Sun C, Zehr M, Abildgaard F, Peng J, Speck NA, Bushweller JH; , Structure Fold Des 1999;7:1247-1256.: The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains. PUBMED:10545320 EPMC:10545320


This clan contains the following 7 member families:

CEP1-DNA_bind NDT80_PhoG P53 RHD Runt STAT_bind T-box

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
T-box (PF00907) 2143 (39.8%) View
RHD (PF00554) 1068 (19.8%) View
STAT_bind (PF02864) 708 (13.1%) View
P53 (PF00870) 550 (10.2%) View
Runt (PF00853) 488 (9.1%) View
NDT80_PhoG (PF05224) 421 (7.8%) View
CEP1-DNA_bind (PF09287) 7 (0.1%) View
Total: 7 Total: 5385 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 12 interactions for this clan. More...

Interacting families
T-box T-box
P53 SH3_1
Runt Runt
STAT_bind SH2


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...