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413  structures 777  species 25  interactions 7386  sequences 200  architectures

Clan: P53-like (CL0073)

Summary

Beta-sandwich DNA-binding domain Add an annotation

This clan contains a variety of DNA-binding domains that contain an immunoglobulin-like fold. It includes the DNA-binding domains of NF-kappaB, NFAT, p53, STAT-1, the T-domain and the Runt domain [1].

This clan contains 7 families and the total number of domains in the clan is 7386. The clan was built by A Bateman.

Literature references

  1. Berardi MJ, Sun C, Zehr M, Abildgaard F, Peng J, Speck NA, Bushweller JH; , Structure Fold Des 1999;7:1247-1256.: The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains. PUBMED:10545320 EPMC:10545320

Members

This clan contains the following 7 member families:

CEP1-DNA_bind NDT80_PhoG P53 RHD_DNA_bind Runt STAT_bind T-box

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
T-box (PF00907) 2763 (37.4%) View
RHD_DNA_bind (PF00554) 1419 (19.2%) View
STAT_bind (PF02864) 997 (13.5%) View
NDT80_PhoG (PF05224) 782 (10.6%) View
P53 (PF00870) 777 (10.5%) View
Runt (PF00853) 640 (8.7%) View
CEP1-DNA_bind (PF09287) 8 (0.1%) View
Total: 7 Total: 7386 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 25 interactions for this clan. More...

Interacting families
A B
CBF_beta Runt
IRF RHD_DNA_bind
NDT80_PhoG NDT80_PhoG
P53 Ank
P53
P53_tetramer
SH3_1
P53_tetramer P53
Polyoma_lg_T_C P53
RHD_DNA_bind bZIP_1
Forkhead
RHD_DNA_bind
TIG
Runt CBF_beta
Runt
SH2 STAT_bind
SH3_1 P53
STAT_alpha STAT_bind
STAT_bind SH2
STAT_alpha
STAT_bind
STAT_int STAT_bind
T-box T-box
Thioredoxin RHD_DNA_bind
TIG RHD_DNA_bind

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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