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75  structures 2236  species 5  interactions 6664  sequences 842  architectures

Clan: PA14 (CL0301)


PA14 superfamily Add an annotation

This clan includes the PA14 domain and related families.

This clan contains 2 families and the total number of domains in the clan is 6664. The clan was built by A Bateman.

Literature references

  1. Rigden DJ, Mello LV, Galperin MY; , Trends Biochem Sci. 2004;29:335-339.: The PA14 domain, a conserved all-beta domain in bacterial toxins, enzymes, adhesins and signaling molecules. PUBMED:15236739 EPMC:15236739


This clan contains the following 2 member families:


Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PA14 (PF07691) 5894 (88.4%) View
GLEYA (PF10528) 770 (11.6%) View
Total: 2 Total: 6664 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 5 interactions for this clan. More...

Interacting families
Glyco_hydro_3 PA14
Glyco_hydro_3_C PA14
PA14 Binary_toxB


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...