Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
250  structures 8888  species 3  interactions 43908  sequences 362  architectures

Clan: PFK (CL0240)


PFK-like superfamily Add an annotation

This clan includes two SCOP superfamilies. Strong similarities between NAD kinases, DAG kinase, sphingosine kinase and PFK have previously been shown[1].

This clan contains 4 families and the total number of domains in the clan is 43908. The clan was built by A Bateman.

Literature references

  1. Labesse G, Douguet D, Assairi L, Gilles AM; , Trends Biochem Sci. 2002;27:273-275.: Diacylglyceride kinases, sphingosine kinases and NAD kinases: distant relatives of 6-phosphofructokinases. PUBMED:12069781 EPMC:12069781


This clan contains the following 4 member families:

DAGK_cat NAD_kinase PFK Pfk_N

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
DAGK_cat (PF00781) 17510 (39.9%) View
PFK (PF00365) 14050 (32.0%) View
NAD_kinase (PF01513) 12273 (28.0%) View
Pfk_N (PF18468) 75 (0.2%) View
Total: 4 Total: 43908 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 3 interactions for this clan. More...

Interacting families
DAGK_cat DAGK_cat
NAD_kinase NAD_kinase


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...