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623  structures 11080  species 70  interactions 107604  sequences 2701  architectures

Clan: PH (CL0266)


PH domain-like superfamily Add an annotation

Members of this clan share a PH-like fold. Many families in this clan bind to short peptide motifs in proteins and are involved in signalling.

This clan contains 38 families and the total number of domains in the clan is 107604. The clan was built by A Bateman.


This clan contains the following 38 member families:

bPH_1 bPH_2 bPH_3 bPH_4 bPH_5 bPH_6 DCP1 DUF1448 DUF1681 FERM_C GRAM ICAP-1_inte_bdg IQ_SEC7_PH IRS Mcp5_PH PH PH_10 PH_11 PH_12 PH_13 PH_2 PH_3 PH_4 PH_5 PH_6 PH_8 PH_9 PH_BEACH PH_TFIIH PID PID_2 PTB Ran_BP1 Rtt106 SSrecog Voldacs Vps36_ESCRT-II WH1

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PH (PF00169) 28479 (26.5%) View
bPH_2 (PF03703) 27656 (25.7%) View
bPH_3 (PF14470) 7277 (6.8%) View
bPH_6 (PF10756) 6058 (5.6%) View
GRAM (PF02893) 4466 (4.2%) View
PID (PF00640) 3858 (3.6%) View
FERM_C (PF09380) 3498 (3.3%) View
Ran_BP1 (PF00638) 2640 (2.5%) View
bPH_1 (PF08000) 2209 (2.1%) View
WH1 (PF00568) 1769 (1.6%) View
Rtt106 (PF08512) 1656 (1.5%) View
PH_BEACH (PF14844) 1579 (1.5%) View
PH_9 (PF15410) 1468 (1.4%) View
IRS (PF02174) 1250 (1.2%) View
bPH_4 (PF06713) 1245 (1.2%) View
PH_13 (PF16652) 1087 (1.0%) View
PH_12 (PF16457) 1062 (1.0%) View
PTB (PF08416) 903 (0.8%) View
bPH_5 (PF10882) 857 (0.8%) View
DCP1 (PF06058) 796 (0.7%) View
Pfam family Num. domains Alignment
SSrecog (PF03531) 760 (0.7%) View
DUF1681 (PF07933) 672 (0.6%) View
Voldacs (PF03517) 666 (0.6%) View
PH_8 (PF15409) 630 (0.6%) View
PH_5 (PF15405) 626 (0.6%) View
PH_10 (PF15411) 531 (0.5%) View
Mcp5_PH (PF12814) 490 (0.5%) View
PH_TFIIH (PF08567) 482 (0.4%) View
Vps36_ESCRT-II (PF11605) 481 (0.4%) View
PH_3 (PF14593) 406 (0.4%) View
IQ_SEC7_PH (PF16453) 397 (0.4%) View
PH_2 (PF08458) 325 (0.3%) View
PID_2 (PF14719) 322 (0.3%) View
PH_11 (PF15413) 286 (0.3%) View
DUF1448 (PF07289) 251 (0.2%) View
PH_4 (PF15404) 186 (0.2%) View
PH_6 (PF15406) 164 (0.2%) View
ICAP-1_inte_bdg (PF10480) 116 (0.1%) View
Total: 38 Total: 107604 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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