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819  structures 3540  species 75  interactions 95282  sequences 3422  architectures

Clan: PH (CL0266)


PH domain-like superfamily Add an annotation

Members of this clan share a PH-like fold. Many families in this clan bind to short peptide motifs in proteins and are involved in signalling.

This clan contains 56 families and the total number of domains in the clan is 95282. The clan was built by A Bateman.


This clan contains the following 56 member families:

BBL5 bPH_1 bPH_2 bPH_3 bPH_4 bPH_5 bPH_6 CARM1 DCP1 DUF1126 DUF1681 DUF3203 FERM_C Glycoprot_B_PH1 Glycoprot_B_PH2 GRAM hSac2 ICAP-1_inte_bdg INPP5B_PH IQ_SEC7_PH IRS Mcp5_PH Myosin_TH1 OCRL_clath_bd PH PH_10 PH_11 PH_12 PH_13 PH_2 PH_3 PH_4 PH_5 PH_6 PH_8 PH_9 PH_BEACH PH_TFIIH PID PID_2 POB3_N Proteasom_Rpn13 PTB Ran_BP1 Rtt106 Sec3-PIP2_bind Sharpin_PH SIN1_PH SPT16 SSrecog UCH_N Voldacs Vps36_ESCRT-II WH1 YcxB ZFYVE21_C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PH (PF00169) 34636 (36.4%) View
GRAM (PF02893) 5712 (6.0%) View
bPH_2 (PF03703) 5390 (5.7%) View
PID (PF00640) 4827 (5.1%) View
FERM_C (PF09380) 4627 (4.9%) View
Ran_BP1 (PF00638) 3256 (3.4%) View
WH1 (PF00568) 2147 (2.3%) View
Rtt106 (PF08512) 2089 (2.2%) View
PH_9 (PF15410) 2055 (2.2%) View
DUF1126 (PF06565) 2008 (2.1%) View
PH_BEACH (PF14844) 1979 (2.1%) View
Myosin_TH1 (PF06017) 1736 (1.8%) View
IRS (PF02174) 1540 (1.6%) View
PH_12 (PF16457) 1493 (1.6%) View
PTB (PF08416) 1071 (1.1%) View
DCP1 (PF06058) 1002 (1.1%) View
bPH_6 (PF10756) 988 (1.0%) View
Proteasom_Rpn13 (PF04683) 901 (0.9%) View
DUF1681 (PF07933) 897 (0.9%) View
SPT16 (PF08644) 890 (0.9%) View
PH_5 (PF15405) 884 (0.9%) View
Sec3-PIP2_bind (PF15277) 856 (0.9%) View
Voldacs (PF03517) 855 (0.9%) View
SSrecog (PF03531) 831 (0.9%) View
POB3_N (PF17292) 799 (0.8%) View
PH_8 (PF15409) 782 (0.8%) View
hSac2 (PF12456) 780 (0.8%) View
bPH_1 (PF08000) 771 (0.8%) View
PH_10 (PF15411) 750 (0.8%) View
Pfam family Num. domains Alignment
PH_TFIIH (PF08567) 687 (0.7%) View
Mcp5_PH (PF12814) 684 (0.7%) View
YcxB (PF14317) 670 (0.7%) View
Vps36_ESCRT-II (PF11605) 616 (0.6%) View
SIN1_PH (PF16979) 563 (0.6%) View
IQ_SEC7_PH (PF16453) 553 (0.6%) View
PH_3 (PF14593) 528 (0.6%) View
PH_2 (PF08458) 502 (0.5%) View
PH_13 (PF16652) 488 (0.5%) View
PH_11 (PF15413) 475 (0.5%) View
PID_2 (PF14719) 392 (0.4%) View
BBL5 (PF07289) 365 (0.4%) View
bPH_4 (PF06713) 311 (0.3%) View
bPH_5 (PF10882) 296 (0.3%) View
bPH_3 (PF14470) 266 (0.3%) View
PH_4 (PF15404) 249 (0.3%) View
PH_6 (PF15406) 221 (0.2%) View
UCH_N (PF16674) 149 (0.2%) View
ICAP-1_inte_bdg (PF10480) 147 (0.2%) View
CARM1 (PF11531) 128 (0.1%) View
ZFYVE21_C (PF16696) 117 (0.1%) View
INPP5B_PH (PF16776) 101 (0.1%) View
OCRL_clath_bd (PF16726) 94 (0.1%) View
Sharpin_PH (PF16764) 73 (0.1%) View
DUF3203 (PF11462) 25 (0.0%) View
Glycoprot_B_PH2 (PF17417) 15 (0.0%) View
Glycoprot_B_PH1 (PF17416) 15 (0.0%) View
Total: 56 Total: 95282
No alignment ℹ

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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