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1125  structures 6574  species 75  interactions 151596  sequences 4414  architectures

Clan: PH (CL0266)

Summary

PH domain-like superfamily Add an annotation

Members of this clan share a PH-like fold. Many families in this clan bind to short peptide motifs in proteins and are involved in signalling.

This clan contains 71 families and the total number of domains in the clan is 151596. The clan was built by A Bateman.

Members

This clan contains the following 71 member families:

BBL5 bPH_1 bPH_2 bPH_3 bPH_4 bPH_5 bPH_6 CARM1 Carm_PH DCP1 DUF1126 DUF1681 DUF3203 EbsA FERM_C Glycoprot_B_PH1 Glycoprot_B_PH2 GRAM hSac2 ICAP-1_inte_bdg INPP5B_PH IQ_SEC7_PH IRS ISP1_C ISP3_C Jak1_Phl Mcp5_PH Myosin_TH1 OCRL_clath_bd PH PH_10 PH_11 PH_12 PH_13 PH_14 PH_15 PH_16 PH_17 PH_18 PH_2 PH_3 PH_4 PH_5 PH_6 PH_8 PH_9 PH_BEACH PH_RBD PH_TFIIH PID PID_2 POB3_N Proteasom_Rpn13 PTB Ran_BP1 Rtt106 SCAB-PH Sec3-PIP2_bind Sharpin_PH SIN1_PH SNX17_FERM_C SPT16 SSrecog SYCP2_SLD UCH_N VID27_PH Voldacs Vps36_ESCRT-II WH1 YcxB ZFYVE21_C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PH (PF00169) 50175 (33.1%) View
bPH_2 (PF03703) 11116 (7.3%) View
GRAM (PF02893) 8404 (5.5%) View
PID (PF00640) 7174 (4.7%) View
FERM_C (PF09380) 7087 (4.7%) View
Ran_BP1 (PF00638) 4764 (3.1%) View
WH1 (PF00568) 3110 (2.1%) View
PH_9 (PF15410) 3001 (2.0%) View
PH_BEACH (PF14844) 2937 (1.9%) View
Rtt106 (PF08512) 2934 (1.9%) View
DUF1126 (PF06565) 2751 (1.8%) View
Myosin_TH1 (PF06017) 2465 (1.6%) View
bPH_6 (PF10756) 2330 (1.5%) View
PH_12 (PF16457) 2202 (1.5%) View
IRS (PF02174) 2128 (1.4%) View
PH_16 (PF17838) 1660 (1.1%) View
PTB (PF08416) 1656 (1.1%) View
bPH_1 (PF08000) 1517 (1.0%) View
DCP1 (PF06058) 1459 (1.0%) View
YcxB (PF14317) 1403 (0.9%) View
PH_RBD (PF12068) 1298 (0.9%) View
Sec3-PIP2_bind (PF15277) 1291 (0.9%) View
DUF1681 (PF07933) 1275 (0.8%) View
Proteasom_Rpn13 (PF04683) 1252 (0.8%) View
SPT16 (PF08644) 1245 (0.8%) View
Voldacs (PF03517) 1227 (0.8%) View
PH_5 (PF15405) 1219 (0.8%) View
SSrecog (PF03531) 1187 (0.8%) View
PH_8 (PF15409) 1163 (0.8%) View
POB3_N (PF17292) 1150 (0.8%) View
PH_14 (PF17787) 1087 (0.7%) View
PH_10 (PF15411) 1075 (0.7%) View
hSac2 (PF12456) 1059 (0.7%) View
Mcp5_PH (PF12814) 967 (0.6%) View
PH_TFIIH (PF08567) 944 (0.6%) View
Vps36_ESCRT-II (PF11605) 854 (0.6%) View
continued
Pfam family Num. domains Alignment
IQ_SEC7_PH (PF16453) 834 (0.6%) View
SIN1_PH (PF16979) 804 (0.5%) View
PH_2 (PF08458) 771 (0.5%) View
PH_11 (PF15413) 754 (0.5%) View
PH_3 (PF14593) 729 (0.5%) View
PH_13 (PF16652) 703 (0.5%) View
bPH_3 (PF14470) 602 (0.4%) View
PID_2 (PF14719) 585 (0.4%) View
PH_17 (PF18012) 557 (0.4%) View
bPH_4 (PF06713) 547 (0.4%) View
Carm_PH (PF17888) 541 (0.4%) View
BBL5 (PF07289) 532 (0.4%) View
VID27_PH (PF17747) 522 (0.3%) View
bPH_5 (PF10882) 484 (0.3%) View
Jak1_Phl (PF17887) 480 (0.3%) View
SNX17_FERM_C (PF18116) 401 (0.3%) View
PH_4 (PF15404) 357 (0.2%) View
SCAB-PH (PF17684) 332 (0.2%) View
PH_6 (PF15406) 308 (0.2%) View
EbsA (PF17255) 248 (0.2%) View
ICAP-1_inte_bdg (PF10480) 207 (0.1%) View
UCH_N (PF16674) 198 (0.1%) View
PH_15 (PF17339) 185 (0.1%) View
CARM1 (PF11531) 185 (0.1%) View
SYCP2_SLD (PF18584) 179 (0.1%) View
ZFYVE21_C (PF16696) 176 (0.1%) View
INPP5B_PH (PF16776) 173 (0.1%) View
OCRL_clath_bd (PF16726) 131 (0.1%) View
Sharpin_PH (PF16764) 96 (0.1%) View
PH_18 (PF18469) 90 (0.1%) View
Glycoprot_B_PH2 (PF17417) 74 (0.0%) View
Glycoprot_B_PH1 (PF17416) 73 (0.0%) View
ISP3_C (PF18045) 62 (0.0%) View
DUF3203 (PF11462) 58 (0.0%) View
ISP1_C (PF18161) 52 (0.0%) View
Total: 71 Total: 151596
No alignment ℹ
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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