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117  structures 5231  species 10  interactions 29721  sequences 241  architectures

Clan: PIN (CL0280)

Summary

PIN domain superfamily Add an annotation

This superfamily contains a variety of nuclease enzymes, including PIN domains and the FLAP exonucleases.

This clan contains 16 families and the total number of domains in the clan is 29721. The clan was built by A Bateman.

Literature references

  1. Glavan F, Behm-Ansmant I, Izaurralde E, Conti E; , EMBO J. 2006;25:5117-5125.: Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. PUBMED:17053788 EPMC:17053788
  2. Glavan F, Behm-Ansmant I, Izaurralde E, Conti E; , EMBO J. 2006;25:5117-5125.: Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. PUBMED:17053788 EPMC:17053788
  3. Anantharaman V, Aravind L; , RNA Biol. 2006; [Epub ahead of print]: The NYN Domains: Novel Predicted RNAses with a PIN Domain-Like Fold. PUBMED:17114934 EPMC:17114934

Members

This clan contains the following 16 member families:

5_3_exonuc_N DUF188 DUF4411 Fcf1 Mut7-C NYN NYN_YacP PIN PIN_2 PIN_3 PIN_4 RNase_Zc3h12a RNase_Zc3h12a_2 UPF0278 XPG_N XRN_N

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PIN (PF01850) 8807 (29.6%) View
5_3_exonuc_N (PF02739) 6210 (20.9%) View
NYN (PF01936) 2912 (9.8%) View
PIN_4 (PF13638) 2263 (7.6%) View
DUF188 (PF02639) 2006 (6.7%) View
XPG_N (PF00752) 1710 (5.8%) View
NYN_YacP (PF05991) 1318 (4.4%) View
PIN_3 (PF13470) 1089 (3.7%) View
XRN_N (PF03159) 896 (3.0%) View
Fcf1 (PF04900) 807 (2.7%) View
RNase_Zc3h12a (PF11977) 659 (2.2%) View
Mut7-C (PF01927) 605 (2.0%) View
DUF4411 (PF14367) 237 (0.8%) View
UPF0278 (PF08745) 103 (0.3%) View
PIN_2 (PF10130) 82 (0.3%) View
RNase_Zc3h12a_2 (PF14626) 17 (0.1%) View
Total: 16 Total: 29721 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 10 interactions for this clan. More...

Interacting families
A B
PIN PIN
Fcf1
5_3_exonuc_N DNA_pol_A
5_3_exonuc
Taq-exonuc
RNaseH_C
Fcf1 PIN
Fcf1
XPG_N XPG_N
XPG_I

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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