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146  structures 20168  species 20  interactions 168383  sequences 339  architectures

Clan: PIN (CL0280)

Summary

PIN domain superfamily Add an annotation

This superfamily contains a variety of nuclease enzymes, including PIN domains and the FLAP exonucleases.

This clan contains 17 families and the total number of domains in the clan is 168383. The clan was built by A Bateman.

Literature references

  1. Glavan F, Behm-Ansmant I, Izaurralde E, Conti E; , EMBO J. 2006;25:5117-5125.: Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. PUBMED:17053788 EPMC:17053788
  2. Glavan F, Behm-Ansmant I, Izaurralde E, Conti E; , EMBO J. 2006;25:5117-5125.: Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. PUBMED:17053788 EPMC:17053788
  3. Anantharaman V, Aravind L; , RNA Biol. 2006; [Epub ahead of print]: The NYN Domains: Novel Predicted RNAses with a PIN Domain-Like Fold. PUBMED:17114934 EPMC:17114934

Members

This clan contains the following 17 member families:

5_3_exonuc_N DUF188 DUF4411 Fcf1 Mut7-C NYN NYN_YacP PIN PIN_2 PIN_3 PIN_4 PRORP RNase_Zc3h12a RNase_Zc3h12a_2 UPF0278 XPG_N XRN_N

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PIN (PF01850) 86558 (51.4%) View
5_3_exonuc_N (PF02739) 30416 (18.1%) View
DUF188 (PF02639) 11594 (6.9%) View
NYN_YacP (PF05991) 9138 (5.4%) View
NYN (PF01936) 8750 (5.2%) View
PIN_4 (PF13638) 6649 (3.9%) View
XPG_N (PF00752) 3271 (1.9%) View
Mut7-C (PF01927) 2709 (1.6%) View
PIN_3 (PF13470) 2484 (1.5%) View
DUF4411 (PF14367) 2025 (1.2%) View
XRN_N (PF03159) 1600 (1.0%) View
Fcf1 (PF04900) 1449 (0.9%) View
RNase_Zc3h12a (PF11977) 917 (0.5%) View
PRORP (PF16953) 443 (0.3%) View
UPF0278 (PF08745) 197 (0.1%) View
PIN_2 (PF10130) 161 (0.1%) View
RNase_Zc3h12a_2 (PF14626) 22 (0.0%) View
Total: 17 Total: 168383 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 20 interactions for this clan. More...

Interacting families
A B
5_3_exonuc 5_3_exonuc_N
5_3_exonuc_N 5_3_exonuc
5_3_exonuc_N
DNA_pol_A
RNaseH_C
Taq-exonuc
MazE_antitoxin PIN
PhdYeFM_antitox PIN
PIN MazE_antitoxin
PIN
RHH_1
PIN_4 PIN_4
RNase_Zc3h12a RNase_Zc3h12a
XPG_I XPG_N
XPG_N PCNA_C
PCNA_N
XPG_I
XPG_N
XRN_N RAI1
XRN_N

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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