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947  structures 7892  species 18  interactions 74811  sequences 429  architectures

Clan: PK_TIM (CL0151)


Pyruvate kinase-like TIM barrel superfamily Add an annotation

This superfamily consists of a number of TIM barrel domains found in enzymes such as pyruvate kinase, malate synthase and citrate lyase.

This clan contains 11 families and the total number of domains in the clan is 74811. The clan was built by A Bateman.


This clan contains the following 11 member families:

C-C_Bond_Lyase HpcH_HpaI ICL Malate_synthase Pantoate_transf PEP-utilizers_C PEP_hydrolase PEP_mutase PEPcase PEPcase_2 PK

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
HpcH_HpaI (PF03328) 13529 (18.1%) View
PEP-utilizers_C (PF02896) 13217 (17.7%) View
PK (PF00224) 13027 (17.4%) View
ICL (PF00463) 7779 (10.4%) View
PEP_mutase (PF13714) 7604 (10.2%) View
Pantoate_transf (PF02548) 6812 (9.1%) View
PEPcase (PF00311) 5799 (7.8%) View
Malate_synthase (PF01274) 5071 (6.8%) View
PEP_hydrolase (PF09370) 1124 (1.5%) View
C-C_Bond_Lyase (PF15617) 727 (1.0%) View
PEPcase_2 (PF14010) 122 (0.2%) View
Total: 11 Total: 74811 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 18 interactions for this clan. More...

Interacting families
HpcH_HpaI HpcH_HpaI
Malate_synthase Malate_synthase
Pantoate_transf Pantoate_transf
PEP-utilisers_N PEP-utilizers_C
PEP-utilizers PEP-utilizers_C
PEP-utilizers_C PEP-utilizers_C
PEP_hydrolase PEP_hydrolase
PEP_mutase PEP_mutase
PEPcase PEPcase
PEPcase_2 PEPcase_2
PK PEP-utilizers
PPDK_N PEP-utilizers_C


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...