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6557  structures 5146  species 115  interactions 382476  sequences 11510  architectures

Clan: PKinase (CL0016)

Summary

Protein kinase superfamily Add an annotation

This superfamily includes the Serine/Threonine- and Tyrosine- protein kinases as well as related kinases that act on non-protein substrates.

This clan contains 35 families and the total number of domains in the clan is 382476. The clan was built by DJ Studholme.

Literature references

  1. Hanks SK, Quinn AM; , Methods Enzymol 1991;200:38-62.: Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. PUBMED:1956325 EPMC:1956325
  2. Hanks SK, Hunter T; , FASEB J 1995;9:576-596.: Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. PUBMED:7768349 EPMC:7768349
  3. Hunter T, Plowman GD; , Trends Biochem Sci 1997;22:18-22.: The protein kinases of budding yeast: six score and more. PUBMED:9020587 EPMC:9020587

Members

This clan contains the following 35 member families:

ABC1 AceK Act-Frag_cataly Alpha_kinase APH APH_6_hur Choline_kinase CotH DUF1679 DUF2252 DUF4135 EcKinase Fam20C Fructosamin_kin FTA2 Haspin_kinase HipA_C Ins_P5_2-kin IPK IucA_IucC Kdo Kinase-like KIND PI3_PI4_kinase PIP49_C PIP5K Pkinase Pkinase_Tyr Pox_ser-thr_kin RIO1 Seadorna_VP7 UL97 WaaY YrbL-PhoP_reg YukC

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Pkinase (PF00069) 236455 (61.8%) View
Pkinase_Tyr (PF07714) 68047 (17.8%) View
APH (PF01636) 23267 (6.1%) View
PI3_PI4_kinase (PF00454) 10601 (2.8%) View
ABC1 (PF03109) 9007 (2.4%) View
PIP5K (PF01504) 5664 (1.5%) View
RIO1 (PF01163) 3305 (0.9%) View
Choline_kinase (PF01633) 3041 (0.8%) View
IPK (PF03770) 2555 (0.7%) View
HipA_C (PF07804) 2296 (0.6%) View
Fructosamin_kin (PF03881) 2284 (0.6%) View
EcKinase (PF02958) 2150 (0.6%) View
Kdo (PF06293) 2126 (0.6%) View
Alpha_kinase (PF02816) 1663 (0.4%) View
IucA_IucC (PF04183) 1390 (0.4%) View
CotH (PF08757) 1178 (0.3%) View
DUF2252 (PF10009) 996 (0.3%) View
Ins_P5_2-kin (PF06090) 854 (0.2%) View
continued
Pfam family Num. domains Alignment
PIP49_C (PF12260) 800 (0.2%) View
DUF1679 (PF07914) 748 (0.2%) View
Haspin_kinase (PF12330) 715 (0.2%) View
APH_6_hur (PF04655) 694 (0.2%) View
Fam20C (PF06702) 625 (0.2%) View
AceK (PF06315) 436 (0.1%) View
KIND (PF16474) 426 (0.1%) View
DUF4135 (PF13575) 301 (0.1%) View
FTA2 (PF13095) 214 (0.1%) View
Act-Frag_cataly (PF09192) 154 (0.0%) View
YrbL-PhoP_reg (PF10707) 130 (0.0%) View
YukC (PF10140) 128 (0.0%) View
WaaY (PF06176) 113 (0.0%) View
Kinase-like (PF14531) 95 (0.0%) View
Pox_ser-thr_kin (PF05445) 12 (0.0%) View
Seadorna_VP7 (PF07387) 3 (0.0%) View
UL97 (PF06734) 3 (0.0%) View
Total: 35 Total: 382476 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 115 interactions for this clan. More...

Interacting families
A B
AceK AceK
Iso_dh
Act-Frag_cataly Act-Frag_cataly
Alpha_kinase Alpha_kinase
APH APH
AvrPto Pkinase_Tyr
C1_1 Pkinase
CaM-KIIN Pkinase
CDKN3 Pkinase
Choline_kinase Choline_kinase
CK_II_beta Pkinase
cNMP_binding Pkinase
Couple_hipA HipA_C
Cyclin Pkinase
Cyclin_C Pkinase
Cyclin_N Pkinase
EphA2_TM Pkinase_Tyr
FAT PI3_PI4_kinase
FERM_M Pkinase_Tyr
FHA Pkinase
FKBP_C Pkinase
fn3 Pkinase
FRB_dom PI3_PI4_kinase
Fructosamin_kin Fructosamin_kin
Herp-Cyclin Pkinase
HipA_C HipA_C
HTH_3
HTH_3 HipA_C
Ins_P5_2-kin Ins_P5_2-kin
IPK IPK
IucA_IucC FhuF
IucA_IucC
Kinase-like Kinase-like
Mo25 Pkinase
PBD Pkinase
Peptidase_M22 Pkinase
PH Pkinase
PI3_PI4_kinase FATC
PI3_PI4_kinase
PI3K_rbd
PI3Ka
Ras
SH2
WD40
PI3K_C2 PI3_PI4_kinase
PI3K_rbd PI3_PI4_kinase
PI3Ka PI3_PI4_kinase
PKI Pkinase
Pkinase AMPKBI
Ank
Ank_2
Ank_4
Aurora-A_bind
CagA
CaM-KIIN
CaMKII_AD
CDI
CDK5_activator
CGI-121
CK1gamma_C
CK_II_beta
CKS
cNMP_binding
Cyclin
Cyclin_C
Cyclin_N
DED
EF-hand_1
EF-hand_5
EF-hand_6
EF-hand_7
EF-hand_8
FHA
FKBP_C
GSK-3_bind
Haspin_kinase
I-set
INCENP_ARK-bind
K-cyclin_vir_C
PB1
PBD
Peptidase_M22
Phospholamban
PKI
Pkinase
Pkinase_C
POLO_box
PP2C
Ras
Rhodanese
Ribonuc_2-5A
RIIa
RRM_1
SAM_1
Tat
TGF_beta_GS
UBA_2
zf-DBF
Pkinase_C Pkinase
Pkinase_Tyr BPS
CH
EphA2_TM
Inhibitor_Mig-6
Pkinase
Pkinase_Tyr
SH2
RGS Pkinase
Ribonuc_2-5A Pkinase
RIO1 RIO1
Rio2_N RIO1
S1 Pkinase
SH2 Pkinase_Tyr
SH3_1 Pkinase_Tyr
TGF_beta_GS Pkinase
Y_phosphatase Pkinase_Tyr

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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