Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
472  structures 505  species 3  interactions 2405  sequences 54  architectures

Clan: PLA2 (CL0629)

Summary

Phospholipase A2 superfamily Add an annotation

This clan contains 4 families and the total number of domains in the clan is 2405. The clan was built by A Bateman.

Literature references

  1. Schaloske RH, Dennis EA;, Biochim Biophys Acta. 2006;1761:1246-1259.: The phospholipase A2 superfamily and its group numbering system. PUBMED:16973413 EPMC:16973413

Members

This clan contains the following 4 member families:

Phospholip_A2_1 Phospholip_A2_2 Phospholip_A2_3 PLA2G12

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...

Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Phospholip_A2_1 (PF00068) 1241 (51.6%) View
Phospholip_A2_2 (PF05826) 513 (21.3%) View
PLA2G12 (PF06951) 329 (13.7%) View
Phospholip_A2_3 (PF09056) 322 (13.4%) View
Total: 4 Total: 2405 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls

Hide

This tree shows the occurrence of the domains in this clan across different species. More...

Loading...

Interactions

There are 3 interactions for this clan. More...

Interacting families
A B
Phospholip_A2_1 Beta-APP
Kunitz_BPTI
Phospholip_A2_1

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...