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518  structures 861  species 3  interactions 4193  sequences 67  architectures

Clan: PLA2 (CL0629)


Phospholipase A2 superfamily Add an annotation

This clan contains 4 families and the total number of domains in the clan is 4193. The clan was built by A Bateman.

Literature references

  1. Schaloske RH, Dennis EA;, Biochim Biophys Acta. 2006;1761:1246-1259.: The phospholipase A2 superfamily and its group numbering system. PUBMED:16973413 EPMC:16973413


This clan contains the following 4 member families:

Phospholip_A2_1 Phospholip_A2_2 Phospholip_A2_3 PLA2G12

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Phospholip_A2_1 (PF00068) 1765 (42.1%) View
Phospholip_A2_2 (PF05826) 1103 (26.3%) View
Phospholip_A2_3 (PF09056) 665 (15.9%) View
PLA2G12 (PF06951) 660 (15.7%) View
Total: 4 Total: 4193 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 3 interactions for this clan. More...

Interacting families
Phospholip_A2_1 Beta-APP


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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