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112  structures 4760  species 6  interactions 26607  sequences 292  architectures

Clan: PLD (CL0479)


Phospholipase D superfamily Add an annotation

This superfamily includes proteins that are related to Phospholiase D.

This clan contains 9 families and the total number of domains in the clan is 26607. The clan was built by A Bateman.


This clan contains the following 9 member families:

DUF1669 MIT_C PLDc PLDc_2 PLDc_3 PP_kinase_C RE_NgoFVII Regulator_TrmB Tyr-DNA_phospho

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PLDc_2 (PF13091) 16514 (62.1%) View
PLDc (PF00614) 3452 (13.0%) View
PP_kinase_C (PF13090) 3025 (11.4%) View
Tyr-DNA_phospho (PF06087) 1414 (5.3%) View
DUF1669 (PF07894) 762 (2.9%) View
PLDc_3 (PF13918) 573 (2.2%) View
Regulator_TrmB (PF11495) 414 (1.6%) View
MIT_C (PF16565) 339 (1.3%) View
RE_NgoFVII (PF09565) 114 (0.4%) View
Total: 9 Total: 26607 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 6 interactions for this clan. More...

Interacting families
PLDc_2 PLDc_2
PP_kinase PP_kinase_C
PP_kinase_C PP_kinase
PP_kinase_N PP_kinase_C
Tyr-DNA_phospho Tyr-DNA_phospho


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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