Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
281  structures 8415  species 14  interactions 89601  sequences 6336  architectures

Clan: PP-binding (CL0314)


ACP-like superfamily Add an annotation

This clan contains 4 families and the total number of domains in the clan is 89601. The clan was built by A Bateman.

Literature references

  1. Byers DM, Gong H; , Biochem Cell Biol. 2007;85:649-662.: Acyl carrier protein: structure-function relationships in a conserved multifunctional protein family. PUBMED:18059524 EPMC:18059524
  2. Leibundgut M, Jenni S, Frick C, Ban N; , Science. 2007;316:288-290.: Structural basis for substrate delivery by acyl carrier protein in the yeast fatty acid synthase. PUBMED:17431182 EPMC:17431182


This clan contains the following 4 member families:

DUF1493 PP-binding PP-binding_2 Ribosomal_L50

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PP-binding (PF00550) 88586 (98.9%) View
Ribosomal_L50 (PF10501) 629 (0.7%) View
DUF1493 (PF07377) 345 (0.4%) View
PP-binding_2 (PF14573) 41 (0.0%) View
Total: 4 Total: 89601 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 14 interactions for this clan. More...

Interacting families
Abhydrolase_6 PP-binding
ACPS PP-binding
AMP-binding PP-binding
AMP-binding_C PP-binding
Condensation PP-binding
FA_desaturase_2 PP-binding
PP-binding AMP-binding
STAS PP-binding
tRNA-synt_2b PP-binding


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...