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40  structures 12  species 8  interactions 68  sequences 2  architectures

Clan: Pept_Inhib_IE (CL0096)


Peptidase Inhibitor Clan IE Add an annotation

The members of this clan are all cystine rich domains, which form a knottin scaffold. This clan should also contain alpha-amylase but currently this family is a singleton and can not be put into Pfam. Also see [1].

This clan contains 2 families and the total number of domains in the clan is 68. The clan was built by RD Finn.

Literature references

  1. Gelly JC, Gracy J, Kaas Q, Le-Nguyen D, Heitz A, Chiche L; , Nucleic Acids Res 2004;32:D156-D159.: The KNOTTIN website and database: a new information system dedicated to the knottin scaffold. PUBMED:14681383 EPMC:14681383


This clan contains the following 2 member families:

CarbpepA_inh Squash

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CarbpepA_inh (PF02977) 65 (95.6%) View
Squash (PF00299) 3 (4.4%) View
Total: 2 Total: 68 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 8 interactions for this clan. More...

Interacting families
CarbpepA_inh CarbpepA_inh
Peptidase_M14 CarbpepA_inh
Ribonuclease Squash
Squash Ribonuclease
Trypsin Squash


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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