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2322  structures 4835  species 27  interactions 196860  sequences 795  architectures

Clan: Peptidase_AA (CL0129)

Summary

Peptidase clan AA Add an annotation

This clan contains aspartic peptidases, including the pepsins and retropepsins. These enzymes contains a catalytic dyad composed of two aspartates. In the retropepsins one is provided by each copy of a homodimeric protein, whereas in the pepsin-like peptidases these aspartates come from a single protein composed of two duplicated domains.

This clan contains 14 families and the total number of domains in the clan is 196860. The clan was built by A Bateman.

Members

This clan contains the following 14 member families:

Asp Asp_protease Asp_protease_2 DUF1758 gag-asp_proteas Peptidase_A2B Peptidase_A2E Peptidase_A3 RVP RVP_2 Spuma_A9PTase TAXi_C TAXi_N Zn_protease

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
RVP (PF00077) 168023 (85.4%) View
Asp (PF00026) 8888 (4.5%) View
Asp_protease_2 (PF13650) 5898 (3.0%) View
TAXi_N (PF14543) 3366 (1.7%) View
Zn_protease (PF05618) 3285 (1.7%) View
TAXi_C (PF14541) 3213 (1.6%) View
RVP_2 (PF08284) 1416 (0.7%) View
gag-asp_proteas (PF13975) 911 (0.5%) View
DUF1758 (PF05585) 838 (0.4%) View
Asp_protease (PF09668) 805 (0.4%) View
Peptidase_A3 (PF02160) 142 (0.1%) View
Spuma_A9PTase (PF03539) 36 (0.0%) View
Peptidase_A2B (PF12384) 27 (0.0%) View
Peptidase_A2E (PF12382) 12 (0.0%) View
Total: 14 Total: 196860 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 27 interactions for this clan. More...

Interacting families
A B
A1_Propeptide Asp
Asp A1_Propeptide
Asp
Inhibitor_I34
Pepsin-I3
SapB_1
SapB_2
Serpin
SH3_1
V-set
Asp_protease Asp_protease
Glyco_hydro_11 TAXi_C
RVP Gag_p17
Gag_p24
Gag_p6
RNase_H
RVP
SapB_2 Asp
Serpin Asp
TAXi_C Glyco_hydro_11
Glyco_hydro_12
TAXi_C
TAXi_N
TAXi_N Glyco_hydro_11
TAXi_C
TAXi_N
Zn_protease Zn_protease

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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