Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
21  structures 12182  species 3  interactions 19654  sequences 57  architectures

Clan: Peptidase_AD (CL0130)


Peptidase clan AD Add an annotation

Members of this clan are peptidases that are integral membrane proteins. The catalytic aspartate is in the conserved GXGD motif.

This clan contains 4 families and the total number of domains in the clan is 19654. The clan was built by A Bateman.


This clan contains the following 4 member families:

Peptidase_A22B Peptidase_A24 Presenilin SPP

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Peptidase_A24 (PF01478) 16887 (85.9%) View
Peptidase_A22B (PF04258) 1745 (8.9%) View
Presenilin (PF01080) 827 (4.2%) View
SPP (PF06550) 195 (1.0%) View
Total: 4 Total: 19654 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 3 interactions for this clan. More...

Interacting families
MHC_I Peptidase_A22B
Peptidase_A24 Arc_PepC_II


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...