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1525  structures 5439  species 78  interactions 125279  sequences 2800  architectures

Clan: Peptidase_MA (CL0126)

Summary

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Peptidase_M48 (PF01435) 12783 (10.2%) View
Peptidase_M1 (PF01433) 11909 (9.5%) View
Peptidase_M41 (PF01434) 9356 (7.5%) View
Peptidase_M3 (PF01432) 8170 (6.5%) View
Peptidase_M50 (PF02163) 7728 (6.2%) View
Astacin (PF01400) 6013 (4.8%) View
Peptidase_M13 (PF01431) 5192 (4.1%) View
UPF0054 (PF02130) 4492 (3.6%) View
Reprolysin (PF01421) 4484 (3.6%) View
Peptidase_M78 (PF06114) 4254 (3.4%) View
Peptidase_M10 (PF00413) 4141 (3.3%) View
DUF45 (PF01863) 3477 (2.8%) View
DUF885 (PF05960) 2467 (2.0%) View
SprT-like (PF10263) 2352 (1.9%) View
Peptidase_M56 (PF05569) 2135 (1.7%) View
Peptidase_M8 (PF01457) 1827 (1.5%) View
Zn_peptidase (PF04228) 1680 (1.3%) View
Peptidase_M4_C (PF02868) 1669 (1.3%) View
Peptidase_M4 (PF01447) 1641 (1.3%) View
Zincin_1 (PF06262) 1497 (1.2%) View
Peptidase_M43 (PF05572) 1467 (1.2%) View
Peptidase_M49 (PF03571) 1461 (1.2%) View
Peptidase_M2 (PF01401) 1351 (1.1%) View
Zn_peptidase_2 (PF04298) 1261 (1.0%) View
Peptidase_M32 (PF02074) 1234 (1.0%) View
Peptidase_M50B (PF13398) 1210 (1.0%) View
WLM (PF08325) 1187 (0.9%) View
Peptidase_M6 (PF05547) 1076 (0.9%) View
Zincin_2 (PF10103) 1037 (0.8%) View
Peptidase_M61 (PF05299) 1034 (0.8%) View
Reprolysin_5 (PF13688) 1027 (0.8%) View
Peptidase_M36 (PF02128) 973 (0.8%) View
Peptidase_M76 (PF09768) 812 (0.6%) View
DUF4953 (PF16313) 806 (0.6%) View
DUF4157 (PF13699) 790 (0.6%) View
Peptidase_M90 (PF06167) 732 (0.6%) View
continued
Pfam family Num. domains Alignment
BSP (PF04450) 676 (0.5%) View
DUF2201_N (PF13203) 654 (0.5%) View
Aspzincin_M35 (PF14521) 611 (0.5%) View
Peptidase_M60 (PF13402) 547 (0.4%) View
Peptidase_M64 (PF09471) 519 (0.4%) View
Metallopep (PF12044) 506 (0.4%) View
Peptidase_Mx (PF15887) 501 (0.4%) View
DA1-like (PF12315) 494 (0.4%) View
Reprolysin_2 (PF13574) 459 (0.4%) View
DUF3152 (PF11350) 455 (0.4%) View
Peptidase_M54 (PF07998) 439 (0.4%) View
DUF3267 (PF11667) 432 (0.3%) View
Reprolysin_4 (PF13583) 426 (0.3%) View
Peptidase_M35 (PF02102) 398 (0.3%) View
DUF2268 (PF10026) 368 (0.3%) View
DUF3810 (PF12725) 349 (0.3%) View
Reprolysin_3 (PF13582) 314 (0.3%) View
Peptidase_M9 (PF01752) 255 (0.2%) View
Aminopep (PF10023) 251 (0.2%) View
DUF4344 (PF14247) 245 (0.2%) View
HRXXH (PF13933) 223 (0.2%) View
Peptidase_M11 (PF05548) 210 (0.2%) View
Peptidase_Mx1 (PF15890) 206 (0.2%) View
Peptidase_M7 (PF02031) 187 (0.1%) View
Peptidase_M57 (PF12388) 183 (0.1%) View
Peptidase_MA_2 (PF13485) 175 (0.1%) View
Peptidase_M91 (PF14891) 127 (0.1%) View
DUF1570 (PF07607) 112 (0.1%) View
Peptidase_M66 (PF10462) 110 (0.1%) View
Peptidase_M30 (PF10460) 44 (0.0%) View
Peptidase_U49 (PF10463) 28 (0.0%) View
ATLF (PF07737) 23 (0.0%) View
Peptidase_M27 (PF01742) 14 (0.0%) View
DUF3920 (PF13058) 9 (0.0%) View
Peptidase_M85 (PF13678) 4 (0.0%) View
Total: 71 Total: 125279
No alignment ℹ
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 78 interactions for this clan. More...

Interacting families
A B
AAA Peptidase_M41
ADAM_CR Reprolysin
Anthrax-tox_M ATLF
Aspzincin_M35 Aspzincin_M35
Astacin MAM
MATH
ATLF ADPrib_exo_Tox
Anthrax-tox_M
Binary_toxB ATLF
DUF885 DUF885
ERAP1_C Peptidase_M1
fn2 Peptidase_M10
FTP Peptidase_M4_C
Hemopexin Peptidase_M10
PDZ Peptidase_M50
PepSY Peptidase_M4
Peptidase_M4_C
Peptidase_M1 Corona_S1
DUF3458
ERAP1_C
Leuk-A4-hydro_C
Peptidase_M1
Tachykinin
Peptidase_M10 Collagen
fn2
Hemopexin
Inh
Peptidase_M10
Peptidase_M10_C
TIMP
Peptidase_M13 Peptidase_M13
Peptidase_M13_N
Peptidase_M13_N Peptidase_M13
Peptidase_M2 Corona_S1
Peptidase_M2
Spike_rec_bind
Peptidase_M27 Peptidase_M27
SNARE
Synaptobrevin
Toxin_R_bind_C
Toxin_R_bind_N
Toxin_trans
Peptidase_M3 Peptidase_M3
Peptidase_M3_N
Peptidase_M32 Peptidase_M32
Peptidase_M3_N Peptidase_M3
Peptidase_M4 PepSY
Peptidase_M4_C
TIL
Peptidase_M41 AAA
Peptidase_M41
Peptidase_M43 Peptidase_M43
Peptidase_M48 Peptidase_M48
Peptidase_M49 Peptidase_M49
Peptidase_M4_C FTP
PepSY
Peptidase_M4
Peptidase_M4_C
TIL
Peptidase_M50 PDZ
Peptidase_M50
Peptidase_M61 PDZ_2
Peptidase_M64 Peptidase_M64
Peptidase_M7 SSI
Peptidase_M9_N Peptidase_M9
PG_binding_1 Peptidase_M10
Reprolysin ADAM_CR
Disintegrin
Reprolysin
Reprolysin_2 Inh
Peptidase_M10_C
Reprolysin_5 Reprolysin_5
TIMP
TIMP Peptidase_M10
Toxin_R_bind_C Peptidase_M27
Toxin_trans Peptidase_M27
UPF0054 UPF0054
Zincin_1 Zincin_1

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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