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981  structures 6188  species 24  interactions 88418  sequences 1676  architectures

Clan: Peptidase_MA (CL0126)


Peptidase clan MA Add an annotation

Clan MA is one of two zinc-dependent metallopeptidases that contain the HEXXH motif. The two histidines are zinc ligands. The structures of this clan show the active site is between its two sub-domains.

This clan contains 54 families and the total number of domains in the clan is 88418. The clan was built by A Bateman.


This clan contains the following 54 member families:

Aspzincin_M35 Astacin BSP DUF1570 DUF2201_N DUF2268 DUF3152 DUF3633 DUF3810 DUF4157 DUF45 DUF955 Enhancin HRXXH M60-like Peptidase_M1 Peptidase_M10 Peptidase_M11 Peptidase_M13 Peptidase_M2 Peptidase_M27 Peptidase_M3 Peptidase_M30 Peptidase_M32 Peptidase_M35 Peptidase_M36 Peptidase_M4 Peptidase_M41 Peptidase_M43 Peptidase_M48 Peptidase_M4_C Peptidase_M50 Peptidase_M50B Peptidase_M54 Peptidase_M56 Peptidase_M57 Peptidase_M6 Peptidase_M61 Peptidase_M64 Peptidase_M66 Peptidase_M7 Peptidase_M8 Peptidase_M9 Peptidase_M91 Peptidase_MA_2 Peptidase_U49 Reprolysin Reprolysin_2 Reprolysin_3 Reprolysin_4 Reprolysin_5 SprT-like WLM Zn_peptidase

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Peptidase_M48 (PF01435) 10571 (12.0%) View
Peptidase_M50 (PF02163) 8451 (9.6%) View
Peptidase_M3 (PF01432) 8043 (9.1%) View
Peptidase_M1 (PF01433) 7280 (8.2%) View
Peptidase_M41 (PF01434) 7039 (8.0%) View
DUF955 (PF06114) 5058 (5.7%) View
DUF45 (PF01863) 3481 (3.9%) View
Peptidase_M13 (PF01431) 3320 (3.8%) View
Peptidase_M10 (PF00413) 3213 (3.6%) View
Reprolysin (PF01421) 3201 (3.6%) View
SprT-like (PF10263) 2631 (3.0%) View
Astacin (PF01400) 2029 (2.3%) View
Peptidase_M4_C (PF02868) 1990 (2.3%) View
Peptidase_MA_2 (PF13485) 1955 (2.2%) View
Peptidase_M4 (PF01447) 1948 (2.2%) View
Peptidase_M56 (PF05569) 1807 (2.0%) View
Zn_peptidase (PF04228) 1671 (1.9%) View
Peptidase_M32 (PF02074) 1205 (1.4%) View
Peptidase_M8 (PF01457) 1086 (1.2%) View
Peptidase_M6 (PF05547) 820 (0.9%) View
M60-like (PF13402) 818 (0.9%) View
Peptidase_M2 (PF01401) 802 (0.9%) View
Peptidase_M61 (PF05299) 668 (0.8%) View
Peptidase_M50B (PF13398) 639 (0.7%) View
Enhancin (PF03272) 631 (0.7%) View
Peptidase_M9 (PF01752) 608 (0.7%) View
Peptidase_M43 (PF05572) 563 (0.6%) View
DUF2268 (PF10026) 528 (0.6%) View
Pfam family Num. domains Alignment
DUF2201_N (PF13203) 492 (0.6%) View
DUF4157 (PF13699) 470 (0.5%) View
Reprolysin_5 (PF13688) 463 (0.5%) View
Peptidase_M36 (PF02128) 458 (0.5%) View
Reprolysin_2 (PF13574) 431 (0.5%) View
WLM (PF08325) 403 (0.5%) View
DUF3152 (PF11350) 313 (0.4%) View
Reprolysin_3 (PF13582) 288 (0.3%) View
Reprolysin_4 (PF13583) 268 (0.3%) View
Peptidase_M54 (PF07998) 267 (0.3%) View
BSP (PF04450) 266 (0.3%) View
Peptidase_M66 (PF10462) 252 (0.3%) View
Peptidase_M64 (PF09471) 251 (0.3%) View
Peptidase_M35 (PF02102) 234 (0.3%) View
Aspzincin_M35 (PF14521) 226 (0.3%) View
Peptidase_M11 (PF05548) 219 (0.2%) View
Peptidase_M27 (PF01742) 216 (0.2%) View
DUF3810 (PF12725) 206 (0.2%) View
DUF3633 (PF12315) 151 (0.2%) View
Peptidase_M91 (PF14891) 118 (0.1%) View
HRXXH (PF13933) 85 (0.1%) View
Peptidase_M7 (PF02031) 82 (0.1%) View
Peptidase_M30 (PF10460) 71 (0.1%) View
Peptidase_M57 (PF12388) 69 (0.1%) View
DUF1570 (PF07607) 34 (0.0%) View
Peptidase_U49 (PF10463) 29 (0.0%) View
Total: 54 Total: 88418 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

We could not retrieve a family relationship diagram for this clan.

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



There are 24 interactions for this clan. More...

Interacting families
Peptidase_M2 Peptidase_M2
Peptidase_M13 Peptidase_M13_N
Reprolysin Disintegrin
Peptidase_M50 Peptidase_M50
Peptidase_M3 Peptidase_M3
Peptidase_M4 Peptidase_M4
Peptidase_M41 AAA
Peptidase_M4_C Peptidase_M4
Peptidase_M1 Leuk-A4-hydro_C
Peptidase_M10 fn2
Peptidase_M27 Peptidase_M27
Peptidase_M32 Peptidase_M32


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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