Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
1759  structures 9283  species 0  interactions 183657  sequences 1955  architectures

Clan: Peptidase_MH (CL0035)


Peptidase clan MH/MC/MF Add an annotation

This clan contains peptidases belonging to MEROPS clan MH, MC and MF. We also include Nicastrin that is part of the gamma secretase complex and not known to be a peptidase.

This clan contains 17 families and the total number of domains in the clan is 183657. The clan was built by A Bateman.


This clan contains the following 17 member families:

Amidase_3 AstE_AspA DUF2817 DUF4910 FGase Gamma_PGA_hydro Glycolytic Ncstrn_small Nicastrin Peptidase_M14 Peptidase_M17 Peptidase_M18 Peptidase_M20 Peptidase_M28 Peptidase_M42 Peptidase_M99 SpoIIP

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Peptidase_M20 (PF01546) 70318 (38.3%) View
Peptidase_M28 (PF04389) 26552 (14.5%) View
Peptidase_M14 (PF00246) 26263 (14.3%) View
Amidase_3 (PF01520) 13527 (7.4%) View
Peptidase_M17 (PF00883) 12121 (6.6%) View
AstE_AspA (PF04952) 6861 (3.7%) View
Peptidase_M18 (PF02127) 6117 (3.3%) View
Glycolytic (PF00274) 5728 (3.1%) View
Peptidase_M42 (PF05343) 5625 (3.1%) View
FGase (PF05013) 4962 (2.7%) View
Nicastrin (PF05450) 1490 (0.8%) View
SpoIIP (PF07454) 1403 (0.8%) View
Ncstrn_small (PF18266) 1106 (0.6%) View
DUF2817 (PF10994) 580 (0.3%) View
DUF4910 (PF16254) 464 (0.3%) View
Gamma_PGA_hydro (PF05908) 413 (0.2%) View
Peptidase_M99 (PF17033) 127 (0.1%) View
Total: 17 Total: 183657 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...