Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
18  structures 2287  species 2  interactions 4463  sequences 18  architectures

Clan: Peptidase_ML (CL0095)


Peptidase Clan ML Add an annotation

This clan contains HybD-like domains. HybD is a nickel binding endopeptidase. Structural and sequences analyses have highlighted the presence of two highly conserved motifs that are shared with germination proteases and HybD [1]. Members of this clan adopt an alpha/beta fold, comprised of a central beta sheet, surrounded by alpha helices.

This clan contains 3 families and the total number of domains in the clan is 4463. The clan was built by RD Finn.

Literature references

  1. Pei J, Grishin NV; , Protein Sci 2003;12:1131-1135.: Peptidase family U34 belongs to the superfamily of N-terminal nucleophile hydrolases. PUBMED:12717035 EPMC:12717035


This clan contains the following 3 member families:

DUF1256 HycI Peptidase_A25

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
HycI (PF01750) 2068 (46.3%) View
Peptidase_A25 (PF03418) 1365 (30.6%) View
DUF1256 (PF06866) 1030 (23.1%) View
Total: 3 Total: 4463 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 2 interactions for this clan. More...

Interacting families
HycI HycI
Peptidase_A25 Peptidase_A25


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...