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51  structures 6506  species 1  interaction 8409  sequences 15  architectures

Clan: Peptidase_SH (CL0201)


Peptidase clan SH Add an annotation

This clan includes the serine peptidase assemblin from herpes virus as well as other viral peptidase families predicted to be related [1].

This clan contains 4 families and the total number of domains in the clan is 8409. The clan was built by A Bateman.

Literature references

  1. Cheng H, Shen N, Pei J, Grishin NV; , Protein Sci 2004;13:2260-2269.: Double-stranded DNA bacteriophage prohead protease is homologous to herpesvirus protease. PUBMED:15273316 EPMC:15273316


This clan contains the following 4 member families:

Peptidase_S21 Peptidase_S77 Peptidase_S78 Peptidase_S78_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Peptidase_S78 (PF04586) 7686 (91.4%) View
Peptidase_S78_2 (PF14550) 306 (3.6%) View
Peptidase_S21 (PF00716) 261 (3.1%) View
Peptidase_S77 (PF03420) 156 (1.9%) View
Total: 4 Total: 8409 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There is 1 interaction for this clan. More...

Interacting families
Peptidase_S21 Peptidase_S21


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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