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577  structures 10946  species 18  interactions 42503  sequences 787  architectures

Clan: Phosphatase (CL0031)

Summary

Phosphatase superfamily Add an annotation

This family includes tyrosine and dual specificity phosphatase enzymes.

This clan contains 10 families and the total number of domains in the clan is 42503. The clan was built by A Bateman.

Literature references

  1. Barford D, Das AK, Egloff MP; , Annu Rev Biophys Biomol Struct 1998;27:133-164.: The structure and mechanism of protein phosphatases: insights into catalysis and regulation. PUBMED:9646865 EPMC:9646865

Members

This clan contains the following 10 member families:

CDKN3 DSPc DSPn DUF442 Init_tRNA_PT Myotub-related PTPlike_phytase Y_phosphatase Y_phosphatase2 Y_phosphatase3

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
DSPc (PF00782) 14168 (33.3%) View
Y_phosphatase (PF00102) 11854 (27.9%) View
Y_phosphatase3 (PF13350) 6326 (14.9%) View
Myotub-related (PF06602) 3107 (7.3%) View
DUF442 (PF04273) 3056 (7.2%) View
Y_phosphatase2 (PF03162) 1578 (3.7%) View
PTPlike_phytase (PF14566) 944 (2.2%) View
DSPn (PF14671) 720 (1.7%) View
Init_tRNA_PT (PF04179) 401 (0.9%) View
CDKN3 (PF05706) 349 (0.8%) View
Total: 10 Total: 42503 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 18 interactions for this clan. More...

Interacting families
A B
CDKN3 CDKN3
Pkinase
DSPc DSPc
PTEN_C2
DSPn DSPc
DUF442 DUF442
GRAM Myotub-related
Ion_trans DSPc
Myotub-related Myotub-related
PTPlike_phytase PTPlike_phytase
SH2 Y_phosphatase
Y_phosphatase ITAM
Pkinase_Tyr
Y_phosphatase
Y_phosphatase2 Y_phosphatase2
Y_phosphatase3 Y_phosphatase3C
Y_phosphatase3C Y_phosphatase3
YopE Y_phosphatase

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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