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110  structures 572  species 11  interactions 6994  sequences 223  architectures

Clan: RGS (CL0272)

Summary

RGS-like superfamily Add an annotation

This clan includes RGS domains that possess an alpha helical fold.

This clan contains 2 families and the total number of domains in the clan is 6994. The clan was built by A Bateman.

Literature references

  1. Ross EM, Wilkie TM; , Annu Rev Biochem. 2000;69:795-827.: GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. PUBMED:10966476 EPMC:10966476

Members

This clan contains the following 2 member families:

RGS RGS-like

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
RGS (PF00615) 6596 (94.3%) View
RGS-like (PF09128) 398 (5.7%) View
Total: 2 Total: 6994 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 11 interactions for this clan. More...

Interacting families
A B
G-alpha RGS
RGS-like
G-gamma RGS
RGS G-alpha
PDE6_gamma
Pkinase
RGS
RhoGEF
SAMP
WD40
RGS-like G-alpha

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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