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110  structures 572  species 11  interactions 6994  sequences 223  architectures

Clan: RGS (CL0272)


RGS-like superfamily Add an annotation

This clan includes RGS domains that possess an alpha helical fold.

This clan contains 2 families and the total number of domains in the clan is 6994. The clan was built by A Bateman.

Literature references

  1. Ross EM, Wilkie TM; , Annu Rev Biochem. 2000;69:795-827.: GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. PUBMED:10966476 EPMC:10966476


This clan contains the following 2 member families:

RGS RGS-like

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
RGS (PF00615) 6596 (94.3%) View
RGS-like (PF09128) 398 (5.7%) View
Total: 2 Total: 6994 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 11 interactions for this clan. More...

Interacting families
G-alpha RGS
G-gamma RGS
RGS G-alpha
RGS-like G-alpha


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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