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110  structures 998  species 3  interactions 4355  sequences 143  architectures

Clan: RIIa (CL0068)


RIIa-like fold Add an annotation

This clan includes both the RIIa dimerisation motif as well as the Dpy-30-like motif [1].

This clan contains 2 families and the total number of domains in the clan is 4355. The clan was built by A Bateman.

Literature references

  1. Roguev A, Schaft D, Shevchenko A, Pijnappel WW, Wilm M, Aasland R, Stewart AF; , EMBO J 2001;20:7137-7148.: The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. PUBMED:11742990 EPMC:11742990


This clan contains the following 2 member families:

Dpy-30 RIIa

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Dpy-30 (PF05186) 2266 (52.0%) View
RIIa (PF02197) 2089 (48.0%) View
Total: 2 Total: 4355 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 3 interactions for this clan. More...

Interacting families
Dpy-30 Dpy-30
Pkinase RIIa


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...