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159  structures 4407  species 11  interactions 49901  sequences 1983  architectures

Clan: RING (CL0229)


Ring-finger/U-box superfamily Add an annotation

This clan includes the Ring zinc finger domains as well as the U-box domain that appears to have lost the zinc coordinating cysteine residues [1].

This clan contains 24 families and the total number of domains in the clan is 49901. The clan was built by A Bateman.

Literature references

  1. Aravind L, Koonin EV; , Curr Biol 2000;10:132-134.: The U box is a modified RING finger - a common domain in ubiquitination. PUBMED:10704423 EPMC:10704423


This clan contains the following 24 member families:

Baculo_RING FANCL_C Prok-RING_1 Prok-RING_2 Prok-RING_4 RINGv Rtf2 U-box zf-Apc11 zf-C3HC4 zf-C3HC4_2 zf-C3HC4_3 zf-C3HC4_4 zf-MIZ zf-Nse zf-rbx1 zf-RING-like zf-RING_2 zf-RING_4 zf-RING_5 zf-RING_6 zf-RING_UBOX zf-UBP zf-UDP

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
zf-RING_2 (PF13639) 15070 (30.2%) View
zf-C3HC4 (PF00097) 9094 (18.2%) View
zf-C3HC4_3 (PF13920) 5985 (12.0%) View
zf-C3HC4_2 (PF13923) 3897 (7.8%) View
zf-C3HC4_4 (PF15227) 3078 (6.2%) View
U-box (PF04564) 2544 (5.1%) View
zf-UBP (PF02148) 2273 (4.6%) View
RINGv (PF12906) 1986 (4.0%) View
zf-MIZ (PF02891) 975 (2.0%) View
zf-rbx1 (PF12678) 903 (1.8%) View
zf-RING_5 (PF14634) 801 (1.6%) View
zf-RING_UBOX (PF13445) 584 (1.2%) View
Rtf2 (PF04641) 575 (1.2%) View
Pfam family Num. domains Alignment
zf-RING_4 (PF14570) 462 (0.9%) View
zf-Nse (PF11789) 399 (0.8%) View
zf-UDP (PF14569) 380 (0.8%) View
zf-Apc11 (PF12861) 247 (0.5%) View
FANCL_C (PF11793) 241 (0.5%) View
zf-RING-like (PF08746) 210 (0.4%) View
zf-RING_6 (PF14835) 67 (0.1%) View
Baculo_RING (PF05883) 57 (0.1%) View
Prok-RING_4 (PF14447) 46 (0.1%) View
Prok-RING_1 (PF14446) 24 (0.0%) View
Prok-RING_2 (PF14445) 3 (0.0%) View
Total: 24 Total: 49901 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 11 interactions for this clan. More...

Interacting families
zf-UBP ubiquitin
U-box UQ_con
zf-C3HC4 zf-C3HC4


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...