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256  structures 9497  species 50  interactions 102628  sequences 2989  architectures

Clan: RING (CL0229)

Summary

Ring-finger/U-box superfamily Add an annotation

This clan includes the Ring zinc finger domains as well as the U-box domain that appears to have lost the zinc coordinating cysteine residues [1].

This clan contains 38 families and the total number of domains in the clan is 102628. The clan was built by A Bateman.

Literature references

  1. Aravind L, Koonin EV; , Curr Biol 2000;10:132-134.: The U box is a modified RING finger - a common domain in ubiquitination. PUBMED:10704423 EPMC:10704423

Members

This clan contains the following 38 member families:

Baculo_IE-1 Baculo_RING DUF1644 FANCL_C IBR Prok-RING_1 Prok-RING_2 Prok-RING_4 RINGv Rtf2 U-box UPF1_Zn_bind zf-ANAPC11 zf-C3H2C3 zf-C3HC4 zf-C3HC4_2 zf-C3HC4_3 zf-C3HC4_4 zf-C3HC4_5 zf-MIZ zf-NOSIP zf-Nse zf-P11 zf-rbx1 zf-RING-like zf-RING_10 zf-RING_11 zf-RING_2 zf-RING_4 zf-RING_5 zf-RING_6 zf-RING_7 zf-RING_9 zf-RING_UBOX zf-UBP zf-UDP zinc_ribbon_16 Zn_ribbon_17

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
zf-RING_2 (PF13639) 24122 (23.5%) View
zf-C3HC4 (PF00097) 16918 (16.5%) View
zf-C3HC4_3 (PF13920) 14362 (14.0%) View
IBR (PF01485) 8523 (8.3%) View
U-box (PF04564) 5396 (5.3%) View
zf-UBP (PF02148) 4125 (4.0%) View
zf-C3HC4_4 (PF15227) 3769 (3.7%) View
RINGv (PF12906) 3681 (3.6%) View
zf-RING_7 (PF02591) 3613 (3.5%) View
zf-RING_UBOX (PF13445) 2075 (2.0%) View
zf-rbx1 (PF12678) 1960 (1.9%) View
zf-MIZ (PF02891) 1753 (1.7%) View
zf-RING_5 (PF14634) 1337 (1.3%) View
zf-C3HC4_2 (PF13923) 999 (1.0%) View
Rtf2 (PF04641) 953 (0.9%) View
zf-RING_4 (PF14570) 943 (0.9%) View
zf-RING_11 (PF17123) 888 (0.9%) View
zf-UDP (PF14569) 776 (0.8%) View
zf-RING_9 (PF13901) 765 (0.7%) View
zf-Nse (PF11789) 648 (0.6%) View
continued
Pfam family Num. domains Alignment
UPF1_Zn_bind (PF09416) 642 (0.6%) View
zf-ANAPC11 (PF12861) 507 (0.5%) View
DUF1644 (PF07800) 500 (0.5%) View
zf-NOSIP (PF15906) 477 (0.5%) View
Zn_ribbon_17 (PF17120) 473 (0.5%) View
zinc_ribbon_16 (PF17034) 437 (0.4%) View
zf-C3HC4_5 (PF17121) 422 (0.4%) View
zf-RING-like (PF08746) 415 (0.4%) View
FANCL_C (PF11793) 308 (0.3%) View
zf-C3H2C3 (PF17122) 182 (0.2%) View
zf-RING_10 (PF16685) 142 (0.1%) View
zf-P11 (PF03854) 129 (0.1%) View
zf-RING_6 (PF14835) 95 (0.1%) View
Baculo_RING (PF05883) 78 (0.1%) View
Prok-RING_1 (PF14446) 75 (0.1%) View
Prok-RING_4 (PF14447) 71 (0.1%) View
Baculo_IE-1 (PF05290) 61 (0.1%) View
Prok-RING_2 (PF14445) 8 (0.0%) View
Total: 38 Total: 102628 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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