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736  structures 5818  species 6  interactions 73704  sequences 1162  architectures

Clan: RRM (CL0221)


RRM-like clan Add an annotation

This clan contains families that are related to the RNA recognition motif domains. However, not all these families are RNA binding.

This clan contains 15 families and the total number of domains in the clan is 73704. The clan was built by A Bateman.


This clan contains the following 15 member families:

BRAP2 Calcipressin DUF1866 Limkain-b1 Nup35_RRM Nup35_RRM_2 Ribosomal_L23 RNA_bind RRM_1 RRM_2 RRM_3 RRM_5 RRM_6 Smg4_UPF3 XS

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
RRM_1 (PF00076) 50512 (68.5%) View
RRM_6 (PF14259) 8811 (12.0%) View
Ribosomal_L23 (PF00276) 6180 (8.4%) View
RRM_5 (PF13893) 5485 (7.4%) View
Smg4_UPF3 (PF03467) 408 (0.6%) View
Calcipressin (PF04847) 405 (0.5%) View
RRM_2 (PF04059) 387 (0.5%) View
RRM_3 (PF08777) 306 (0.4%) View
BRAP2 (PF07576) 297 (0.4%) View
Nup35_RRM (PF05172) 252 (0.3%) View
XS (PF03468) 211 (0.3%) View
DUF1866 (PF08952) 189 (0.3%) View
Nup35_RRM_2 (PF14605) 98 (0.1%) View
RNA_bind (PF08675) 85 (0.1%) View
Limkain-b1 (PF11608) 78 (0.1%) View
Total: 15 Total: 73704 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



There are 6 interactions for this clan. More...

Interacting families
Nup35_RRM Nup35_RRM


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...