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1186  structures 21591  species 13  interactions 310468  sequences 2308  architectures

Clan: RdRP (CL0027)


RNA dependent RNA polymerase Add an annotation

This clan represents the replicative RNA dependent RNA polymerase. from a variety of RNA viruses [1].

This clan contains 9 families and the total number of domains in the clan is 310468. The clan was built by A Bateman.

Literature references

  1. Koonin EV; , J Gen Virol 1991;72:2197-2206.: The phylogeny of RNA-dependent RNA polymerases of positive-strand RNA viruses. PUBMED:1895057 EPMC:1895057


This clan contains the following 9 member families:

Birna_RdRp Flavi_NS5 Mitovir_RNA_pol RdRP_1 RdRP_2 RdRP_3 RdRP_4 RVT_1 RVT_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
RVT_1 (PF00078) 244283 (78.7%) View
RdRP_3 (PF00998) 24337 (7.8%) View
RdRP_1 (PF00680) 20248 (6.5%) View
RVT_2 (PF07727) 8526 (2.7%) View
Flavi_NS5 (PF00972) 6455 (2.1%) View
RdRP_2 (PF00978) 3914 (1.3%) View
RdRP_4 (PF02123) 2044 (0.7%) View
Birna_RdRp (PF04197) 472 (0.2%) View
Mitovir_RNA_pol (PF05919) 189 (0.1%) View
Total: 9 Total: 310468 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 13 interactions for this clan. More...

Interacting families
Birna_RdRp Birna_RdRp
Flavi_NS5 Flavi_NS5
FtsJ Flavi_NS5
RdRP_1 RdRP_1
RdRP_3 RdRP_3
RdRP_4 Rotavirus_VP1
Rota_VP2 RdRP_4
RVT_connect RVT_1
Telomerase_RBD RVT_1


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...