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472  structures 764  species 19  interactions 13804  sequences 591  architectures

Clan: SH2-like (CL0541)

Summary

SH2, phosphotyrosine-recognition domain superfamily Add an annotation

This superfamily is characterised by proteins with the SH2-like fold. The proesence of this domain guides signal-transduction towards the phosphorylated tyrosine residues on its interacting protein-partner.

This clan contains 2 families and the total number of domains in the clan is 13804. The clan was built by P Coggill.

Literature references

  1. Tong L, Warren TC, King J, Betageri R, Rose J, Jakes S;, J Mol Biol. 1996;256:601-610.: Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution. PUBMED:8604142 EPMC:8604142

Members

This clan contains the following 2 member families:

SH2 SH2_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SH2 (PF00017) 13161 (95.3%) View
SH2_2 (PF14633) 643 (4.7%) View
Total: 2 Total: 13804 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 19 interactions for this clan. More...

Interacting families
A B
PI3_PI4_kinase SH2
PI3K_C2 SH2
PI3Ka SH2
Pkinase_Tyr SH2
SH2 APP_amyloid
C1_1
C2
DUF3513
ITAM
Pkinase_Tyr
SH2
SH3_1
SH3_2
SOCS_box
STAT_bind
Y_phosphatase
SH2_2 SH2_2
SH3_1 SH2
STAT_bind SH2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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