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960  structures 5379  species 26  interactions 41311  sequences 196  architectures

Clan: SIS (CL0067)

Summary

SIS domain fold Add an annotation

This catalytic domain catalyses isomerisation reactions of a variety of sugars [1].

This clan contains 7 families and the total number of domains in the clan is 41311. The clan was built by A Bateman.

Literature references

  1. Bateman A; , Trends Biochem Sci 1999;24:94-95.: The SIS domain: a phosphosugar-binding domain. PUBMED:10203754 EPMC:10203754

Members

This clan contains the following 7 member families:

bact-PGI_C DUF2529 HobA PGI Ribosomal_S2 SIS SIS_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SIS (PF01380) 23489 (56.9%) View
Ribosomal_S2 (PF00318) 7887 (19.1%) View
PGI (PF00342) 5691 (13.8%) View
SIS_2 (PF13580) 3442 (8.3%) View
bact-PGI_C (PF10432) 631 (1.5%) View
DUF2529 (PF10740) 123 (0.3%) View
HobA (PF12163) 48 (0.1%) View
Total: 7 Total: 41311 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 26 interactions for this clan. More...

Interacting families
A B
bact-PGI_C bact-PGI_C
SIS
DUF2529 DUF2529
GATase_2 SIS
HobA HobA
HTH_6 SIS
PGI PGI
Ribosomal_S17e Ribosomal_S2
Ribosomal_S2 Ribosomal_L3
Ribosomal_S17e
Ribosomal_S2
Ribosomal_S21
Ribosomal_S21e
Ribosomal_S28e
Ribosomal_S3_C
Ribosomal_S5
Ribosomal_S8
Ribosomal_S9
WD40
Ribosomal_S26e Ribosomal_S2
Ribosomal_S5 Ribosomal_S2
SIS bact-PGI_C
GATase_2
SIS
SIS_2 SIS_2
WD40 Ribosomal_S2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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