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156  structures 315  species 5  interactions 5322  sequences 225  architectures

Clan: SOCS_box (CL0642)


SOCS-box like superfamily Add an annotation

This superfamily includes the SOCS-box domain and the VHL-box domain [1].

This clan contains 2 families and the total number of domains in the clan is 5322. The clan was built by A Bateman.

Literature references

  1. Kamura T, Maenaka K, Kotoshiba S, Matsumoto M, Kohda D, Conaway RC, Conaway JW, Nakayama KI;, Genes Dev. 2004;18:3055-3065.: VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. PUBMED:15601820 EPMC:15601820


This clan contains the following 2 member families:


External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SOCS_box (PF07525) 5183 (97.4%) View
VHL_C (PF17211) 139 (2.6%) View
Total: 2 Total: 5322 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 5 interactions for this clan. More...

Interacting families
Ank SOCS_box
Ank_2 SOCS_box
SH2 SOCS_box
SOCS_box Cullin


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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