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109  structures 238  species 5  interactions 3908  sequences 207  architectures

Clan: SOCS_box (CL0642)

Summary

SOCS-box like superfamily Add an annotation

This superfamily includes the SOCS-box domain and the VHL-box domain [1].

This clan contains 2 families and the total number of domains in the clan is 3908. The clan was built by A Bateman.

Literature references

  1. Kamura T, Maenaka K, Kotoshiba S, Matsumoto M, Kohda D, Conaway RC, Conaway JW, Nakayama KI;, Genes Dev. 2004;18:3055-3065.: VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. PUBMED:15601820 EPMC:15601820

Members

This clan contains the following 2 member families:

SOCS_box VHL_C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SOCS_box (PF07525) 3810 (97.5%) View
VHL_C (PF17211) 98 (2.5%) View
Total: 2 Total: 3908 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 5 interactions for this clan. More...

Interacting families
A B
Ank SOCS_box
Ank_2 SOCS_box
SH2 SOCS_box
SOCS_box Cullin
Skp1_POZ

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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