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15  structures 1958  species 5  interactions 5139  sequences 128  architectures

Clan: SPOC (CL0616)

Summary

SPOC domain-like superfamily Add an annotation

The crystal structure of the SPOC domain [3] showed it has similarity with the beta barrel domain of the Ku proteins. These domains share a 7 stranded beta barrel. In the Ku proteins this domain interacts DNA, whereas the SPOC domain mediates protein binding.

This clan contains 3 families and the total number of domains in the clan is 5139. The clan was built by A Bateman.

Literature references

  1. Sanchez-Pulido L, Rojas AM, van Wely KH, Martinez-A C, Valencia A;, BMC Bioinformatics. 2004;5:91.: SPOC: a widely distributed domain associated with cancer, apoptosis and transcription. PUBMED:15239844 EPMC:15239844
  2. Mikami S, Kanaba T, Ito Y, Mishima M;, Biomol NMR Assign. 2013;7:267-270.: NMR assignments of SPOC domain of the human transcriptional corepressor SHARP in complex with a C-terminal SMRT peptide. PUBMED:22987228 EPMC:22987228
  3. Ariyoshi M, Schwabe JW; , Genes Dev 2003;17:1909-1920.: A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling. PUBMED:12897056 EPMC:12897056

Members

This clan contains the following 3 member families:

Ku Med25 SPOC

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Ku (PF02735) 3147 (61.2%) View
SPOC (PF07744) 1732 (33.7%) View
Med25 (PF11232) 260 (5.1%) View
Total: 3 Total: 5139 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 5 interactions for this clan. More...

Interacting families
A B
Ku Ku
Ku_C
Ku_N
Ku_C Ku
Ku_N Ku

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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