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26  structures 377  species 5  interactions 17032  sequences 746  architectures

Clan: SRCR (CL0550)


SRCR-like Add an annotation

This clan contains 3 families and the total number of domains in the clan is 17032. The clan was built by R Eberhardt.

Literature references

  1. Somoza JR, Ho JD, Luong C, Ghate M, Sprengeler PA, Mortara K, Shrader WD, Sperandio D, Chan H, McGrath ME, Katz BA; , Structure. 2003;11:1123-1131.: The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain. PUBMED:12962630 EPMC:12962630


This clan contains the following 3 member families:


External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SRCR (PF00530) 16005 (94.0%) View
SRCR_2 (PF15494) 923 (5.4%) View
Hepsin-SRCR (PF09272) 104 (0.6%) View
Total: 3 Total: 17032 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 5 interactions for this clan. More...

Interacting families
Hepsin-SRCR Hepsin-SRCR
SRCR Ldl_recept_a
Trypsin Hepsin-SRCR


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...