Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
23  structures 719  species 2  interactions 1396  sequences 33  architectures

Clan: SRP9_14 (CL0623)

Summary

SRP alu RNA binding heterodimer, SRP9/14 superfamily Add an annotation

This superfamily represents both the 9 kDa SRP9 and the 14 kDa SRP14 components. Both SRP9 and SRP14 have the same (beta)-alpha-beta(3)-alpha fold. The heterodimer has pseudo two-fold symmetry and is saddle-like, consisting of a curved six-stranded beta-sheet that has four helices packed on the convex side and an exposed concave surface lined with positively charged residues. The SRP9/SRP14 heterodimer is essential for SRP RNA binding, mediating the pausing of synthesis of ribosome associated nascent polypeptides that have been engaged by the targeting domain of SRP.

This clan contains 2 families and the total number of domains in the clan is 1396. The clan was built by A Bateman.

Literature references

  1. Hsu K, Chang DY, Maraia RJ; , J Biol Chem 1995;270:10179-10186.: Human signal recognition particle (SRP) Alu-associated protein also binds Alu interspersed repeat sequence RNAs. Characterization of human SRP9. PUBMED:7730321 EPMC:7730321

Members

This clan contains the following 2 member families:

SRP14 SRP9-21

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...

Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SRP14 (PF02290) 752 (53.9%) View
SRP9-21 (PF05486) 644 (46.1%) View
Total: 2 Total: 1396 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls

Hide

This tree shows the occurrence of the domains in this clan across different species. More...

Loading...

Interactions

There are 2 interactions for this clan. More...

Interacting families
A B
SRP14 SRP14
SRP9-21 SRP14

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...