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515  structures 2737  species 1  interaction 9033  sequences 85  architectures

Clan: Sm-like (CL0527)


Sm (Small RNA binding protein domain) Add an annotation

Conserved domain of core RNA-binding proteins of mRNA splicing and rRNA processing complexes, with a SH3-like Beta-barrel

This clan contains 3 families and the total number of domains in the clan is 9033. The clan was built by V Anantharaman.

Literature references

  1. Toro I, Thore S, Mayer C, Basquin J, Seraphin B, Suck D;, EMBO J. 2001;20:2293-2303.: RNA binding in an Sm core domain: X-ray structure and functional analysis of an archaeal Sm protein complex. PUBMED:11331594 EPMC:11331594
  2. Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Luhrmann R, Li J, Nagai K; , Cell 1999;96:375-387.: Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs. PUBMED:10025403 EPMC:10025403
  3. Anantharaman V, Koonin EV, Aravind L;, Nucleic Acids Res. 2002;30:1427-1464.: Comparative genomics and evolution of proteins involved in RNA metabolism. PUBMED:11917006 EPMC:11917006
  4. Neuwald AF, Koonin EV; , J Mol Med 1998;76:3-5.: Ataxin-2, global regulators of bacterial gene expression, and spliceosomal snRNP proteins share a conserved domain. PUBMED:9462862 EPMC:9462862
  5. Anantharaman V, Aravind L;, BMC Genomics. 2004;5:45.: Novel conserved domains in proteins with predicted roles in eukaryotic cell-cycle regulation, decapping and RNA stability. PUBMED:15257761 EPMC:15257761


This clan contains the following 3 member families:


Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
LSM (PF01423) 8102 (89.7%) View
LSM14 (PF12701) 564 (6.2%) View
SM-ATX (PF14438) 367 (4.1%) View
Total: 3 Total: 9033 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



There is 1 interaction for this clan. More...

Interacting families


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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