Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
102  structures 398  species 9  interactions 3467  sequences 165  architectures

Clan: TIMP-like (CL0353)


TIMP-like superfamily Add an annotation

This superfamily consists of the C-terminal domains of netrins, complement proteins C3, C4, C5, secreted frizzled-related proteins, and type I procollagen C-proteinase enhancer proteins, as well as the homologous N-terminal domains of tissue inhibitors of metalloproteinases (TIMPs).

This clan contains 3 families and the total number of domains in the clan is 3467. The clan was built by A Bateman.


This clan contains the following 3 member families:


External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
NTR (PF01759) 2247 (64.8%) View
TIMP (PF00965) 1038 (29.9%) View
NtA (PF03146) 182 (5.2%) View
Total: 3 Total: 3467 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 9 interactions for this clan. More...

Interacting families
A2M_recep NTR
Hemopexin TIMP
NTR Sushi
Peptidase_M10 TIMP
Reprolysin_5 TIMP
TIMP Peptidase_M10


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...