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3478  structures 8722  species 0  interactions 1838929  sequences 54914  architectures

Clan: TPR (CL0020)

Summary

Tetratrico peptide repeat superfamily Add an annotation

Tetratricopeptide-like repeats are found in a numerous and diverse proteins involved in such functions as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding.

This clan contains 176 families and the total number of domains in the clan is 1838929. The clan was built by DJ Studholme.

Literature references

  1. Lamb JR, Tugendreich S, Hieter P; , Trends Biochem Sci 1995;20:257-259.: Tetratrico peptide repeat interactions: to TPR or not to TPR? PUBMED:7667876 EPMC:7667876
  2. Das AK, Cohen PW, Barford D; , EMBO J 1998;17:1192-1199.: The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions. PUBMED:9482716 EPMC:9482716
  3. Pallen MJ, Francis MS, Futterer K; , FEMS Microbiol Lett 2003;223:53-60.: Tetratricopeptide-like repeats in type-III-secretion chaperones and regulators. PUBMED:12799000 EPMC:12799000
  4. Rispal D, Henri J, van Tilbeurgh H, Graille M, Seraphin B;, RNA. 2011; [Epub ahead of print]: Structural and functional analysis of Nro1/Ett1: a protein involved in translation termination in S. cerevisiae and in O2-mediated gene control in S. pombe. PUBMED:21610214 EPMC:21610214

Members

This clan contains the following 176 member families:

Adaptin_N Alkyl_sulf_dimr ANAPC3 ANAPC5 ANAPC8 APC_rep API5 Arm Arm_2 Arm_3 Arm_vescicular Atx10homo_assoc B56 BAF250_C BTAD CAS_CSE1 ChAPs CHIP_TPR_N CID CLASP_N Clathrin Clathrin-link Clathrin_H_link Clathrin_propel Cnd1 Cnd3 Coatomer_E Cohesin_HEAT Cohesin_load ComR_TPR COPI_C CPL CRM1_C CRM1_repeat CRM1_repeat_3 Cse1 CTK3 DHR-2 DIL DNA_alkylation Dopey_N Drf_FH3 Drf_GBD DUF1822 DUF2019 DUF2225 DUF3385 DUF3458_C DUF3808 DUF3856 DUF4042 DUF5588 DUF5691 DUF6340 DUF6377 DUF924 EAD11 EST1 EST1_DNA_bind FAT Fis1_TPR_C Fis1_TPR_N Foie-gras_1 GUN4_N HAT HEAT HEAT_2 HEAT_EZ HEAT_PBS HEAT_UF HemY_N HrpB1_HrpK HSM3_C HSM3_N IBB IBN_N IFRD Importin_rep Importin_rep_2 Importin_rep_3 Importin_rep_4 Importin_rep_5 Importin_rep_6 Insc_C KAP Leuk-A4-hydro_C LRV LRV_FeS MA3 MIF4G MIF4G_like MIF4G_like_2 MMS19_C Mo25 MRP-S27 Mtf2 NARP1 Neurochondrin Nipped-B_C Nro1 NSF Paf67 ParcG PC_rep PHAT PI3Ka PknG_TPR PPP5 PPR PPR_1 PPR_2 PPR_3 PPR_long PPTA Proteasom_PSMB PUF Rapsyn_N RIX1 RNPP_C RPM2 RPN7 Sel1 SHNi-TPR SNAP SPO22 SRP_TPR_like ST7 Suf SusD-like SusD-like_2 SusD-like_3 SusD_RagB SYCP2_ARLD TAF6_C TAL_effector TAtT Tcf25 TIP120 TOM20_plant TPR_1 TPR_10 TPR_11 TPR_12 TPR_14 TPR_15 TPR_16 TPR_17 TPR_18 TPR_19 TPR_2 TPR_20 TPR_21 TPR_22 TPR_3 TPR_4 TPR_5 TPR_6 TPR_7 TPR_8 TPR_9 TPR_MalT TTC7_N UNC45-central Upf2 V-ATPase_H_C V-ATPase_H_N Vac14_Fab1_bd Vitellogenin_N Vps39_1 W2 WSLR Wzy_C_2 Xpo1 YcaO_C YfiO Zmiz1_N

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PPR_2 (PF13041) 279811 (15.2%) View
PPR (PF01535) 241615 (13.1%) View
Sel1 (PF08238) 133325 (7.3%) View
TPR_12 (PF13424) 114885 (6.2%) View
TPR_16 (PF13432) 95565 (5.2%) View
TPR_8 (PF13181) 93178 (5.1%) View
Arm (PF00514) 85142 (4.6%) View
PUF (PF00806) 57203 (3.1%) View
TPR_19 (PF14559) 35622 (1.9%) View
TPR_1 (PF00515) 33427 (1.8%) View
HEAT_2 (PF13646) 32371 (1.8%) View
TPR_11 (PF13414) 29497 (1.6%) View
PPR_3 (PF13812) 28278 (1.5%) View
Clathrin (PF00637) 24464 (1.3%) View
TPR_10 (PF13374) 23374 (1.3%) View
SusD_RagB (PF07980) 21774 (1.2%) View
SusD-like_3 (PF14322) 21165 (1.2%) View
Adaptin_N (PF01602) 19462 (1.1%) View
PPR_1 (PF12854) 18483 (1.0%) View
IBN_N (PF03810) 17305 (0.9%) View
PPTA (PF01239) 16557 (0.9%) View
TPR_2 (PF07719) 16441 (0.9%) View
BTAD (PF03704) 13312 (0.7%) View
MIF4G (PF02854) 13138 (0.7%) View
TPR_6 (PF13174) 11860 (0.6%) View
TPR_7 (PF13176) 10860 (0.6%) View
MA3 (PF02847) 10178 (0.6%) View
HEAT (PF02985) 9508 (0.5%) View
CID (PF04818) 9433 (0.5%) View
CLASP_N (PF12348) 9245 (0.5%) View
DHR-2 (PF06920) 8342 (0.5%) View
Xpo1 (PF08389) 8192 (0.4%) View
Drf_GBD (PF06371) 8022 (0.4%) View
PPR_long (PF17177) 7988 (0.4%) View
Clathrin_propel (PF01394) 7640 (0.4%) View
DIL (PF01843) 7287 (0.4%) View
PI3Ka (PF00613) 7060 (0.4%) View
W2 (PF02020) 6806 (0.4%) View
B56 (PF01603) 6797 (0.4%) View
HEAT_EZ (PF13513) 6772 (0.4%) View
FAT (PF02259) 6680 (0.4%) View
TPR_MalT (PF17874) 6654 (0.4%) View
PC_rep (PF01851) 6616 (0.4%) View
Drf_FH3 (PF06367) 6476 (0.4%) View
YfiO (PF13525) 5767 (0.3%) View
Arm_3 (PF16186) 5093 (0.3%) View
IBB (PF01749) 4936 (0.3%) View
DNA_alkylation (PF08713) 4839 (0.3%) View
SNAP (PF14938) 4627 (0.3%) View
SusD-like_2 (PF12771) 4000 (0.2%) View
EST1_DNA_bind (PF10373) 3929 (0.2%) View
Cse1 (PF08506) 3770 (0.2%) View
TPR_20 (PF14561) 3751 (0.2%) View
DUF3808 (PF10300) 3731 (0.2%) View
RPN7 (PF10602) 3618 (0.2%) View
TPR_21 (PF09976) 3297 (0.2%) View
Vitellogenin_N (PF01347) 3078 (0.2%) View
DUF3458_C (PF17432) 3056 (0.2%) View
Suf (PF05843) 3030 (0.2%) View
Leuk-A4-hydro_C (PF09127) 3014 (0.2%) View
Clathrin_H_link (PF13838) 2960 (0.2%) View
Cnd1 (PF12717) 2921 (0.2%) View
Mo25 (PF08569) 2902 (0.2%) View
NARP1 (PF12569) 2810 (0.2%) View
EST1 (PF10374) 2744 (0.1%) View
DUF924 (PF06041) 2706 (0.1%) View
Vac14_Fab1_bd (PF12755) 2487 (0.1%) View
TPR_17 (PF13431) 2437 (0.1%) View
HAT (PF02184) 2382 (0.1%) View
CRM1_C (PF08767) 2353 (0.1%) View
Vps39_1 (PF10366) 2323 (0.1%) View
PPP5 (PF08321) 2321 (0.1%) View
TPR_14 (PF13428) 2271 (0.1%) View
Cohesin_HEAT (PF12765) 2256 (0.1%) View
IFRD (PF05004) 2244 (0.1%) View
TPR_4 (PF07721) 2231 (0.1%) View
Coatomer_E (PF04733) 2224 (0.1%) View
Clathrin-link (PF09268) 2192 (0.1%) View
COPI_C (PF06957) 2181 (0.1%) View
HemY_N (PF07219) 2145 (0.1%) View
V-ATPase_H_N (PF03224) 2114 (0.1%) View
Importin_rep_4 (PF18808) 2110 (0.1%) View
TAF6_C (PF07571) 2080 (0.1%) View
CRM1_repeat_3 (PF18787) 2020 (0.1%) View
Importin_rep_6 (PF18829) 1998 (0.1%) View
TIP120 (PF08623) 1997 (0.1%) View
ANAPC5 (PF12862) 1991 (0.1%) View
Foie-gras_1 (PF11817) 1988 (0.1%) View
ST7 (PF04184) 1978 (0.1%) View
continued
Pfam family Num. domains Alignment
DUF3385 (PF11865) 1944 (0.1%) View
V-ATPase_H_C (PF11698) 1913 (0.1%) View
CRM1_repeat (PF18777) 1909 (0.1%) View
Dopey_N (PF04118) 1902 (0.1%) View
CAS_CSE1 (PF03378) 1890 (0.1%) View
Paf67 (PF10255) 1861 (0.1%) View
Nipped-B_C (PF12830) 1847 (0.1%) View
Tcf25 (PF04910) 1783 (0.1%) View
TPR_9 (PF13371) 1764 (0.1%) View
Cnd3 (PF12719) 1749 (0.1%) View
Fis1_TPR_C (PF14853) 1743 (0.1%) View
Alkyl_sulf_dimr (PF14863) 1727 (0.1%) View
MIF4G_like_2 (PF09090) 1681 (0.1%) View
UNC45-central (PF11701) 1659 (0.1%) View
Upf2 (PF04050) 1639 (0.1%) View
Cohesin_load (PF10345) 1632 (0.1%) View
MIF4G_like (PF09088) 1624 (0.1%) View
KAP (PF05804) 1591 (0.1%) View
MMS19_C (PF12460) 1574 (0.1%) View
Arm_2 (PF04826) 1516 (0.1%) View
SHNi-TPR (PF10516) 1504 (0.1%) View
CPL (PF08144) 1498 (0.1%) View
ANAPC8 (PF04049) 1477 (0.1%) View
BAF250_C (PF12031) 1466 (0.1%) View
Fis1_TPR_N (PF14852) 1461 (0.1%) View
HEAT_PBS (PF03130) 1458 (0.1%) View
Atx10homo_assoc (PF09759) 1445 (0.1%) View
SRP_TPR_like (PF17004) 1396 (0.1%) View
RIX1 (PF08167) 1364 (0.1%) View
ParcG (PF10274) 1331 (0.1%) View
TTC7_N (PF19440) 1327 (0.1%) View
API5 (PF05918) 1217 (0.1%) View
ChAPs (PF09295) 1197 (0.1%) View
Neurochondrin (PF05536) 1163 (0.1%) View
TPR_15 (PF13429) 1058 (0.1%) View
TOM20_plant (PF06552) 1056 (0.1%) View
PknG_TPR (PF16918) 1038 (0.1%) View
SPO22 (PF08631) 1038 (0.1%) View
Proteasom_PSMB (PF10508) 1034 (0.1%) View
TPR_5 (PF12688) 976 (0.1%) View
DUF4042 (PF13251) 964 (0.1%) View
Importin_rep_5 (PF18816) 925 (0.1%) View
SusD-like (PF12741) 871 (0.0%) View
Importin_rep_3 (PF18806) 861 (0.0%) View
Importin_rep_2 (PF18786) 742 (0.0%) View
CTK3 (PF12243) 736 (0.0%) View
APC_rep (PF18797) 731 (0.0%) View
MRP-S27 (PF10037) 721 (0.0%) View
DUF2225 (PF09986) 709 (0.0%) View
Arm_vescicular (PF18770) 700 (0.0%) View
Mtf2 (PF19189) 699 (0.0%) View
DUF5691 (PF18944) 696 (0.0%) View
Importin_rep (PF18773) 679 (0.0%) View
WSLR (PF20023) 665 (0.0%) View
TPR_22 (PF18833) 632 (0.0%) View
TPR_3 (PF07720) 622 (0.0%) View
LRV (PF01816) 620 (0.0%) View
DUF6377 (PF19904) 599 (0.0%) View
YcaO_C (PF18381) 596 (0.0%) View
Insc_C (PF19427) 568 (0.0%) View
DUF1822 (PF08852) 530 (0.0%) View
CHIP_TPR_N (PF18391) 528 (0.0%) View
Wzy_C_2 (PF11846) 486 (0.0%) View
Zmiz1_N (PF18028) 435 (0.0%) View
Rapsyn_N (PF10579) 429 (0.0%) View
TAL_effector (PF03377) 373 (0.0%) View
DUF5588 (PF17826) 356 (0.0%) View
SYCP2_ARLD (PF18581) 321 (0.0%) View
RNPP_C (PF18768) 275 (0.0%) View
TAtT (PF16811) 242 (0.0%) View
DUF6340 (PF19867) 217 (0.0%) View
LRV_FeS (PF05484) 198 (0.0%) View
DUF2019 (PF09450) 132 (0.0%) View
HSM3_N (PF18795) 129 (0.0%) View
Nro1 (PF12753) 125 (0.0%) View
GUN4_N (PF16416) 116 (0.0%) View
EAD11 (PF19964) 112 (0.0%) View
RPM2 (PF08579) 84 (0.0%) View
HrpB1_HrpK (PF09613) 83 (0.0%) View
ComR_TPR (PF18710) 64 (0.0%) View
HSM3_C (PF18794) 57 (0.0%) View
PHAT (PF09246) 56 (0.0%) View
TPR_18 (PF13512) 50 (0.0%) View
DUF3856 (PF12968) 18 (0.0%) View
NSF (PF02071) 11 (0.0%) View
HEAT_UF (PF18817) 2 (0.0%) View
ANAPC3 (PF12895) 0 (0.0%) View
Total: 176 Total: 1838929
No alignment ℹ
 

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Family relationships

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Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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