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1556  structures 22577  species 260  interactions 1013152  sequences 31597  architectures

Clan: TPR (CL0020)

Summary

Tetratrico peptide repeat superfamily Add an annotation

Tetratricopeptide-like repeats are found in a numerous and diverse proteins involved in such functions as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding.

This clan contains 127 families and the total number of domains in the clan is 1013152. The clan was built by DJ Studholme.

Literature references

  1. Lamb JR, Tugendreich S, Hieter P; , Trends Biochem Sci 1995;20:257-259.: Tetratrico peptide repeat interactions: to TPR or not to TPR? PUBMED:7667876 EPMC:7667876
  2. Das AK, Cohen PW, Barford D; , EMBO J 1998;17:1192-1199.: The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions. PUBMED:9482716 EPMC:9482716
  3. Pallen MJ, Francis MS, Futterer K; , FEMS Microbiol Lett 2003;223:53-60.: Tetratricopeptide-like repeats in type-III-secretion chaperones and regulators. PUBMED:12799000 EPMC:12799000
  4. Rispal D, Henri J, van Tilbeurgh H, Graille M, Seraphin B;, RNA. 2011; [Epub ahead of print]: Structural and functional analysis of Nro1/Ett1: a protein involved in translation termination in S. cerevisiae and in O2-mediated gene control in S. pombe. PUBMED:21610214 EPMC:21610214

Members

This clan contains the following 127 member families:

Adaptin_N Alkyl_sulf_dimr ANAPC3 ANAPC5 API5 Arm Arm_2 Arm_3 Avirulence BTAD CAS_CSE1 ChAPs CLASP_N Clathrin Clathrin-link Clathrin_propel Cnd1 Cnd3 Coatomer_E Cohesin_HEAT Cohesin_load COPI_C CRM1_C Cse1 DNA_alkylation Drf_FH3 Drf_GBD DUF1822 DUF2225 DUF3385 DUF3458 DUF3808 DUF3856 DUF4042 DUF924 EST1 EST1_DNA_bind FAT Fis1_TPR_C Fis1_TPR_N Foie-gras_1 GUN4_N HAT HEAT HEAT_2 HEAT_EZ HEAT_PBS HemY_N IBB IBN_N IFRD KAP Leuk-A4-hydro_C LRV LRV_FeS MA3 MIF4G MIF4G_like MIF4G_like_2 Mo25 MRP-S27 NARP1 Neurochondrin Nipped-B_C Nro1 NSF Paf67 ParcG PC_rep PHAT PI3Ka PknG_TPR PPP5 PPR PPR_1 PPR_2 PPR_3 PPTA Proteasom_PSMB PUF Rab5-bind Rapsyn_N RPN7 Sel1 SHNi-TPR SNAP SPO22 SRP_TPR_like ST7 Suf SusD SusD-like SusD-like_2 SusD-like_3 TAF6_C TAtT Tcf25 TOM20_plant TPR_1 TPR_10 TPR_11 TPR_12 TPR_14 TPR_15 TPR_16 TPR_17 TPR_18 TPR_19 TPR_2 TPR_20 TPR_21 TPR_3 TPR_4 TPR_5 TPR_6 TPR_7 TPR_8 TPR_9 Upf2 V-ATPase_H_C V-ATPase_H_N Vac14_Fab1_bd Vitellogenin_N Vps39_1 W2 Xpo1 YfiO

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Sel1 (PF08238) 155578 (15.4%) View
TPR_11 (PF13414) 123888 (12.2%) View
PPR_2 (PF13041) 79201 (7.8%) View
PPR (PF01535) 64551 (6.4%) View
TPR_2 (PF07719) 51893 (5.1%) View
TPR_12 (PF13424) 50478 (5.0%) View
TPR_19 (PF14559) 36257 (3.6%) View
HEAT_2 (PF13646) 35329 (3.5%) View
TPR_8 (PF13181) 34884 (3.4%) View
TPR_1 (PF00515) 34738 (3.4%) View
Arm (PF00514) 22493 (2.2%) View
TPR_6 (PF13174) 18445 (1.8%) View
TPR_9 (PF13371) 18118 (1.8%) View
SusD (PF07980) 18052 (1.8%) View
SusD-like_3 (PF14322) 17716 (1.7%) View
TPR_16 (PF13432) 14104 (1.4%) View
PUF (PF00806) 13246 (1.3%) View
PPR_3 (PF13812) 11121 (1.1%) View
YfiO (PF13525) 10069 (1.0%) View
BTAD (PF03704) 8762 (0.9%) View
TPR_10 (PF13374) 8494 (0.8%) View
TPR_20 (PF14561) 7787 (0.8%) View
Clathrin (PF00637) 7756 (0.8%) View
ANAPC3 (PF12895) 7593 (0.7%) View
DNA_alkylation (PF08713) 7206 (0.7%) View
PPR_1 (PF12854) 6992 (0.7%) View
DUF3458 (PF11940) 6800 (0.7%) View
Adaptin_N (PF01602) 6747 (0.7%) View
TPR_21 (PF09976) 6527 (0.6%) View
Alkyl_sulf_dimr (PF14863) 5666 (0.6%) View
HemY_N (PF07219) 5664 (0.6%) View
IBN_N (PF03810) 5588 (0.6%) View
TPR_3 (PF07720) 5503 (0.5%) View
PPTA (PF01239) 5078 (0.5%) View
TPR_7 (PF13176) 4863 (0.5%) View
MIF4G (PF02854) 4683 (0.5%) View
DUF924 (PF06041) 3086 (0.3%) View
MA3 (PF02847) 3063 (0.3%) View
HEAT (PF02985) 2799 (0.3%) View
Xpo1 (PF08389) 2743 (0.3%) View
PC_rep (PF01851) 2702 (0.3%) View
TPR_15 (PF13429) 2608 (0.3%) View
CLASP_N (PF12348) 2472 (0.2%) View
FAT (PF02259) 2354 (0.2%) View
PI3Ka (PF00613) 2305 (0.2%) View
PknG_TPR (PF16918) 2102 (0.2%) View
W2 (PF02020) 2073 (0.2%) View
Drf_GBD (PF06371) 2058 (0.2%) View
HEAT_EZ (PF13513) 2041 (0.2%) View
SusD-like_2 (PF12771) 1929 (0.2%) View
Clathrin_propel (PF01394) 1814 (0.2%) View
SNAP (PF14938) 1762 (0.2%) View
Drf_FH3 (PF06367) 1730 (0.2%) View
Arm_3 (PF16186) 1628 (0.2%) View
IBB (PF01749) 1571 (0.2%) View
SusD-like (PF12741) 1501 (0.1%) View
EST1_DNA_bind (PF10373) 1469 (0.1%) View
TPR_14 (PF13428) 1462 (0.1%) View
Vitellogenin_N (PF01347) 1446 (0.1%) View
TPR_17 (PF13431) 1430 (0.1%) View
RPN7 (PF10602) 1316 (0.1%) View
Cse1 (PF08506) 1235 (0.1%) View
Suf (PF05843) 1184 (0.1%) View
TPR_4 (PF07721) 1135 (0.1%) View
continued
Pfam family Num. domains Alignment
Leuk-A4-hydro_C (PF09127) 1083 (0.1%) View
Cnd1 (PF12717) 1032 (0.1%) View
NARP1 (PF12569) 983 (0.1%) View
Mo25 (PF08569) 978 (0.1%) View
DUF3808 (PF10300) 953 (0.1%) View
TPR_5 (PF12688) 952 (0.1%) View
Avirulence (PF03377) 937 (0.1%) View
PPP5 (PF08321) 889 (0.1%) View
CRM1_C (PF08767) 872 (0.1%) View
EST1 (PF10374) 861 (0.1%) View
COPI_C (PF06957) 827 (0.1%) View
Coatomer_E (PF04733) 822 (0.1%) View
V-ATPase_H_N (PF03224) 815 (0.1%) View
HAT (PF02184) 789 (0.1%) View
Paf67 (PF10255) 786 (0.1%) View
Vac14_Fab1_bd (PF12755) 775 (0.1%) View
DUF3385 (PF11865) 756 (0.1%) View
Cohesin_HEAT (PF12765) 747 (0.1%) View
Foie-gras_1 (PF11817) 747 (0.1%) View
V-ATPase_H_C (PF11698) 737 (0.1%) View
TAF6_C (PF07571) 732 (0.1%) View
Clathrin-link (PF09268) 731 (0.1%) View
IFRD (PF05004) 727 (0.1%) View
ANAPC5 (PF12862) 721 (0.1%) View
HEAT_PBS (PF03130) 714 (0.1%) View
Fis1_TPR_C (PF14853) 706 (0.1%) View
Vps39_1 (PF10366) 706 (0.1%) View
ChAPs (PF09295) 700 (0.1%) View
CAS_CSE1 (PF03378) 692 (0.1%) View
Tcf25 (PF04910) 656 (0.1%) View
DUF2225 (PF09986) 649 (0.1%) View
Nipped-B_C (PF12830) 633 (0.1%) View
Cnd3 (PF12719) 611 (0.1%) View
MIF4G_like_2 (PF09090) 606 (0.1%) View
Arm_2 (PF04826) 597 (0.1%) View
Upf2 (PF04050) 573 (0.1%) View
Fis1_TPR_N (PF14852) 566 (0.1%) View
ParcG (PF10274) 564 (0.1%) View
MIF4G_like (PF09088) 553 (0.1%) View
SHNi-TPR (PF10516) 532 (0.1%) View
SRP_TPR_like (PF17004) 512 (0.1%) View
ST7 (PF04184) 512 (0.1%) View
KAP (PF05804) 474 (0.0%) View
Cohesin_load (PF10345) 468 (0.0%) View
Proteasom_PSMB (PF10508) 418 (0.0%) View
Neurochondrin (PF05536) 415 (0.0%) View
API5 (PF05918) 357 (0.0%) View
SPO22 (PF08631) 352 (0.0%) View
Rab5-bind (PF09311) 346 (0.0%) View
LRV (PF01816) 345 (0.0%) View
DUF1822 (PF08852) 311 (0.0%) View
DUF4042 (PF13251) 266 (0.0%) View
MRP-S27 (PF10037) 240 (0.0%) View
TOM20_plant (PF06552) 232 (0.0%) View
TAtT (PF16811) 143 (0.0%) View
Rapsyn_N (PF10579) 137 (0.0%) View
LRV_FeS (PF05484) 104 (0.0%) View
GUN4_N (PF16416) 99 (0.0%) View
TPR_18 (PF13512) 92 (0.0%) View
Nro1 (PF12753) 74 (0.0%) View
PHAT (PF09246) 31 (0.0%) View
NSF (PF02071) 14 (0.0%) View
DUF3856 (PF12968) 12 (0.0%) View
Total: 127 Total: 1013152 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

We could not retrieve a family relationship diagram for this clan.

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 260 interactions for this clan. More...

Interacting families
A B
Adaptin_N Adap_comp_sub
Adaptin_N
Arf
Clat_adaptor_s
Alkyl_sulf_C Alkyl_sulf_dimr
Alkyl_sulf_dimr Alkyl_sulf_C
Alkyl_sulf_dimr
Lactamase_B
ANAPC3 ANAPC3
HSP90
TPR_1
ANAPC_CDC26 TPR_1
Arf Adaptin_N
Arm APC_15aa
APC_crr
Arm
Axin_b-cat_bind
Cadherin_C
Cse1
CTNNB1_binding
Flu_PB2
Hormone_recep
IBB
ICAT
Ig_3
Ku_C
Myc_N
Nucleoplasmin
NUP50
Parathyroid
Snurportin1
zf-C4
Arrestin_C Clathrin_propel
Arrestin_N Clathrin_propel
Avirulence Avirulence
B56 HEAT_2
BCL9 Arm
BTAD BTAD
FHA
Trans_reg_C
ChAPs ChAPs
Clat_adaptor_s Adaptin_N
Clathrin Clathrin
Clathrin_lg_ch
Clathrin-link Clathrin_H_link
Clathrin_propel
Clathrin_H_link Clathrin_propel
Clathrin_propel Clathrin-link
Clathrin_propel
Coatomer_E Coatomer_E
COPI_C
Coatomer_WDAD COPI_C
COPI_C Coatomer_E
COPI_C
CRM1_C CRM1_C
Ras
Cse1 CAS_CSE1
IBN_N
DEAD MA3
MIF4G
DNA_alkylation DNA_alkylation
Drf_DAD Drf_FH3
Drf_GBD
Drf_FH3 Drf_DAD
Drf_FH3
Drf_GBD
FH2
Drf_GBD Drf_DAD
Drf_FH3
Drf_GBD
Ras
DUF3856 DUF3856
DUF924 DUF924
EF-hand_1 PI3Ka
EST1 EST1_DNA_bind
EST1_DNA_bind EST1_DNA_bind
FAT PI3_PI4_kinase
FHA BTAD
Fis1_TPR_C DUF3249
Fis1_TPR_C
Mdv1
Fis1_TPR_N DUF3249
Fis1_TPR_C
Mdv1
FKBP_C TPR_1
TPR_11
Glyco_transf_41 TPR_1
TPR_11
HEAT B56
DnaJ
EF-hand_7
Papo_T_antigen
HEAT_2 B56
DnaJ
HEAT
HEAT_2
Metallophos
Papo_T_antigen
HEAT_EZ HEAT_EZ
HLH
HnRNP_M
Helicase_C MA3
MIF4G
HSP70 TPR_11
TPR_2
IBB Arm
Cse1
IBN_N
IBN_N CAS_CSE1
CRM1_C
Parathyroid
Ras
Xpo1
Lactamase_B Alkyl_sulf_dimr
LRV LRV
MA3 DEAD
Helicase_C
MA3
Mago_nashi Xpo1
Metallophos PPP5
MHC_I Arm
MIF4G MIF4G
MIF4G_like
MIF4G_like_2
MIF4G_like MIF4G_like_2
RRM_1
MIF4G_like_2 MIF4G_like_2
RRM_1
Mo25 Mo25
Pkinase
NARP1 Acetyltransf_1
Nro1 Nro1
Nucleoplasmin Arm
PC_rep JAB
PC_rep
Peptidase_M1 DUF3458
Leuk-A4-hydro_C
PI3_PI4_kinase PI3Ka
PI3K_C2 PI3Ka
PI3K_rbd PI3Ka
PI3Ka PI3_PI4_kinase
Pik1
SH2
PPP5 Metallophos
PPP5
PPTA GDI
PPTA
Prenyltrans
RabGGT_insert
SQHop_cyclase_N
Prenyltrans PPTA
Proteasome TPR_15
PUF PUF
Rab5-bind Rab5-bind
TPR_12
TPR_2
Ran_BP1 CRM1_C
Ras CAS_CSE1
CRM1_C
Cse1
Drf_FH3
Drf_GBD
IBN_N
TPR_1
Xpo1
RPN7 PCI
RRM_1 Xpo1
SAM_1 PHAT
Sel1 Sel1
Smg4_UPF3 MIF4G
SNAP SNAP
SQHop_cyclase_N PPTA
Suf CSTF2_hinge
Suf
SusD SusD
SusD-like_3
SusD-like SusD-like
SusD-like_2 SusD-like_2
SusD-like_3 SusD
SusD-like_3
TPR_1 ANAPC3
ANAPC_CDC26
FKBP_C
Glyco_transf_41
GoLoco
HSP90
Metallophos
PPP5
SCP2
TPR_1
TPR_10
TPR_11
TPR_12
TPR_16
TPR_2
TPR_6
TPR_7
TPR_8
TPR_10 TPR_10
TPR_12
TPR_11 ANAPC3
Glyco_transf_41
HSP90
TPR_1
TPR_11
TPR_12
TPR_16
TPR_19
TPR_2
TPR_6
TPR_8
U-box
TPR_12 Response_reg
TPR_1
TPR_10
TPR_11
TPR_12
TPR_19
TPR_7
TPR_15 PCI
TPR_1
TPR_11
TPR_15
TPR_16
TPR_16 TPR_11
TPR_15
TPR_6
TPR_19 TPR_11
TPR_12
TPR_19
TPR_20
TPR_2 Sel1
TPR_1
TPR_11
TPR_2
TPR_6
TPR_8
TPR_20 TPR_19
TPR_20
TPR_3 TPR_3
TPR_6 TPR_1
TPR_6
TPR_7 TPR_1
TPR_7
TPR_8 TPR_1
TPR_2
TPR_8
Trans_reg_C BTAD
UPF1_Zn_bind Upf2
UQ_con IBN_N
Xpo1
V-ATPase_H_N V-ATPase_H_C
Vitellogenin_N DUF1943
DUF1944
W2 W2
Xpo1 CRM1_C
Ras
Xpo1
YfiO Lipoprotein_18
YfiO

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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