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149  structures 2803  species 2  interactions 12513  sequences 389  architectures

Clan: TRASH (CL0175)


TRASH superfamily Add an annotation

TRASH-like domains contain well-conserved cysteine residues that are thought to be involved in metal coordination. These domains are thus expected to be involved in metal trafficking and heavy-metal resistance. It has been suggested that the members adopt a 'treble-clef' fold, with 3/4 beta strands preceding a C-terminal alpha helix [1].

This clan contains 11 families and the total number of domains in the clan is 12513. The clan was built by M Fenech.

Literature references

  1. Ettema TJ, Huynen MA, de Vos WM, van der Oost J; , Trends Biochem Sci 2003;28:170-173.: TRASH: a novel metal-binding domain predicted to be involved in heavy-metal sensing, trafficking and resistance. PUBMED:12713899 EPMC:12713899


This clan contains the following 11 member families:

Arc_trans_TRASH ATPase-cat_bd DUF2256 DUF329 DUF581 Ribosomal_L24e YHS zf-FCS zf-HIT zf-Mss51 zf-MYND

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
zf-MYND (PF01753) 3934 (31.4%) View
zf-FCS (PF06467) 1780 (14.2%) View
YHS (PF04945) 1534 (12.3%) View
DUF329 (PF03884) 1426 (11.4%) View
zf-HIT (PF04438) 1073 (8.6%) View
Ribosomal_L24e (PF01246) 1060 (8.5%) View
ATPase-cat_bd (PF12156) 725 (5.8%) View
DUF581 (PF04570) 427 (3.4%) View
DUF2256 (PF10013) 341 (2.7%) View
zf-Mss51 (PF13824) 148 (1.2%) View
Arc_trans_TRASH (PF08394) 65 (0.5%) View
Total: 11 Total: 12513 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 2 interactions for this clan. More...

Interacting families
YHS Phenol_Hydrox


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...