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268  structures 5380  species 21  interactions 35439  sequences 748  architectures

Clan: TRASH (CL0175)


TRASH superfamily Add an annotation

TRASH-like domains contain well-conserved cysteine residues that are thought to be involved in metal coordination. These domains are thus expected to be involved in metal trafficking and heavy-metal resistance. It has been suggested that the members adopt a 'treble-clef' fold, with 3/4 beta strands preceding a C-terminal alpha helix [1].

This clan contains 12 families and the total number of domains in the clan is 35439. The clan was built by M Fenech.

Literature references

  1. Ettema TJ, Huynen MA, de Vos WM, van der Oost J; , Trends Biochem Sci 2003;28:170-173.: TRASH: a novel metal-binding domain predicted to be involved in heavy-metal sensing, trafficking and resistance. PUBMED:12713899 EPMC:12713899


This clan contains the following 12 member families:

Arc_trans_TRASH ATPase-cat_bd DUF2256 Ribosomal_L24e YacG YHS zf-C6H2 zf-FCS zf-FLZ zf-HIT zf-Mss51 zf-MYND

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
zf-MYND (PF01753) 14427 (40.7%) View
zf-HIT (PF04438) 3430 (9.7%) View
YHS (PF04945) 3195 (9.0%) View
zf-FCS (PF06467) 3190 (9.0%) View
Ribosomal_L24e (PF01246) 3009 (8.5%) View
YacG (PF03884) 2086 (5.9%) View
zf-FLZ (PF04570) 1906 (5.4%) View
ATPase-cat_bd (PF12156) 1415 (4.0%) View
zf-C6H2 (PF15801) 1329 (3.8%) View
DUF2256 (PF10013) 822 (2.3%) View
zf-Mss51 (PF13824) 515 (1.5%) View
Arc_trans_TRASH (PF08394) 115 (0.3%) View
Total: 12 Total: 35439 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 21 interactions for this clan. More...

Interacting families
eIF-6 Ribosomal_L24e
Phenol_Hydrox YHS
Ribosomal_L14 Ribosomal_L24e
Ribosomal_L18A Ribosomal_L24e
Ribosomal_L24e Ribosomal_L29
Ribosomal_L3 Ribosomal_L24e
Ribosomal_L30 Ribosomal_L24e
Ribosomal_L30_N Ribosomal_L24e
Ribosomal_L37ae Ribosomal_L24e
Ribosomal_L38e Ribosomal_L24e
Ribosomal_L40e Ribosomal_L24e
Ribosomal_L44 Ribosomal_L24e
Ribosomal_L6 Ribosomal_L24e
Ribosomal_L7Ae Ribosomal_L24e
YHS Phenol_Hydrox


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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