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2989  structures 22799  species 91  interactions 547046  sequences 1605  architectures

Clan: Thioredoxin (CL0172)

Summary

Thioredoxin-like Add an annotation

This clan contains families related to the thioredoxin family. Thioredoxins are small enzymes that are involved in redox reactions via the reversible oxidation of an active centre disulfide bond. The thioredoxin fold consists of a 3 layer alpha/beta/alpha sandwich and a central beta sheet.

This clan contains 52 families and the total number of domains in the clan is 547046. The clan was built by J Mistry.

Literature references

  1. Qi Y, Grishin NV; , Proteins 2005;58:376-388.: Structural classification of thioredoxin-like fold proteins. PUBMED:15558583 EPMC:15558583

Members

This clan contains the following 52 member families:

2Fe-2S_thioredx AhpC-TSA AhpC-TSA_2 Aminopep ArsC ArsD Calsequestrin DIM1 DSBA DUF1223 DUF1525 DUF1687 DUF2703 DUF2847 DUF4174 DUF836 DUF899 DUF953 ERp29_N Glutaredoxin GSHPx GST_N GST_N_2 GST_N_3 HyaE KaiB L51_S25_CI-B8 Metallopep MRP-S23 MRP-S25 Peptidase_M76 Phosducin Redoxin SCO1-SenC SelP_N Sep15_SelM SH3BGR T4_deiodinase Thioredox_DsbH Thioredoxin Thioredoxin_2 Thioredoxin_3 Thioredoxin_4 Thioredoxin_5 Thioredoxin_6 Thioredoxin_7 Thioredoxin_8 Thioredoxin_9 Tom37 TraF YtfJ_HI0045 Zincin_1

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Thioredoxin (PF00085) 88141 (16.1%) View
AhpC-TSA (PF00578) 74231 (13.6%) View
GST_N_3 (PF13417) 52964 (9.7%) View
Glutaredoxin (PF00462) 41891 (7.7%) View
ArsC (PF03960) 34904 (6.4%) View
Redoxin (PF08534) 30224 (5.5%) View
GST_N (PF02798) 29656 (5.4%) View
DSBA (PF01323) 22730 (4.2%) View
GSHPx (PF00255) 22011 (4.0%) View
Thioredoxin_4 (PF13462) 17389 (3.2%) View
2Fe-2S_thioredx (PF01257) 14354 (2.6%) View
Thioredoxin_2 (PF13098) 14113 (2.6%) View
Thioredoxin_3 (PF13192) 13672 (2.5%) View
Thioredoxin_7 (PF13899) 9535 (1.7%) View
GST_N_2 (PF13409) 7420 (1.4%) View
SCO1-SenC (PF02630) 6779 (1.2%) View
Thioredoxin_5 (PF13743) 6021 (1.1%) View
Zincin_1 (PF06262) 5161 (0.9%) View
YtfJ_HI0045 (PF09695) 5142 (0.9%) View
Thioredoxin_9 (PF14595) 5078 (0.9%) View
DUF2847 (PF11009) 4739 (0.9%) View
Thioredox_DsbH (PF03190) 4623 (0.8%) View
DUF836 (PF05768) 4543 (0.8%) View
Thioredoxin_8 (PF13905) 4100 (0.7%) View
HyaE (PF07449) 3543 (0.6%) View
TraF (PF13728) 3516 (0.6%) View
Thioredoxin_6 (PF13848) 2777 (0.5%) View
continued
Pfam family Num. domains Alignment
Phosducin (PF02114) 2178 (0.4%) View
ArsD (PF06953) 1658 (0.3%) View
DUF899 (PF05988) 1492 (0.3%) View
L51_S25_CI-B8 (PF05047) 1440 (0.3%) View
AhpC-TSA_2 (PF13911) 1125 (0.2%) View
DUF1223 (PF06764) 945 (0.2%) View
DUF4174 (PF13778) 925 (0.2%) View
DIM1 (PF02966) 880 (0.2%) View
DUF1525 (PF07511) 868 (0.2%) View
Aminopep (PF10023) 792 (0.1%) View
Peptidase_M76 (PF09768) 635 (0.1%) View
SH3BGR (PF04908) 623 (0.1%) View
KaiB (PF07689) 620 (0.1%) View
DUF953 (PF06110) 568 (0.1%) View
T4_deiodinase (PF00837) 507 (0.1%) View
Tom37 (PF10568) 454 (0.1%) View
Metallopep (PF12044) 408 (0.1%) View
Sep15_SelM (PF08806) 329 (0.1%) View
MRP-S25 (PF13741) 294 (0.1%) View
Calsequestrin (PF01216) 267 (0.0%) View
DUF1687 (PF07955) 241 (0.0%) View
MRP-S23 (PF10484) 166 (0.0%) View
ERp29_N (PF07912) 142 (0.0%) View
SelP_N (PF04592) 128 (0.0%) View
DUF2703 (PF10865) 104 (0.0%) View
Total: 52 Total: 547046 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

We could not retrieve a family relationship diagram for this clan.

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 91 interactions for this clan. More...

Interacting families
A B
1-cysPrx_C AhpC-TSA
2Fe-2S_thioredx 2Fe-2S_thioredx
NADH_Oxid_Nqo15
AhpC-TSA 1-cysPrx_C
AhpC-TSA
ParBc
ArsC ArsC
RNA_pol_A_CTD
ArsD ArsD
Calsequestrin Calsequestrin
Complex1_30kDa 2Fe-2S_thioredx
Complex1_49kDa 2Fe-2S_thioredx
Complex1_51K 2Fe-2S_thioredx
DIM1 DIM1
GYF
DNA_pol_A Thioredoxin
DnaJ Thioredoxin
DSBA DSBA
DsbB
DsbB DSBA
DsbC Redoxin
Thioredoxin_7
DsbC_N Thioredoxin_2
DUF836 DUF836
ERp29_N ERp29
ERp29_N
FeThRed_A Thioredoxin
FeThRed_B Thioredoxin
Glutaredoxin Glutaredoxin
GST_C_3
Pyr_redox_2
GSHPx GSHPx
GST_C GST_N
GST_N_3
GST_C_2 GST_N
GST_N_2
GST_N_3
GST_C_3 Glutaredoxin
GST_N
GST_N_3
GST_N GST_C
GST_C_2
GST_C_3
GST_N
GST_N_2 GST_C
GST_C_2
GST_N_2
GST_N_3 Glutaredoxin2_C
GST_C
GST_C_2
GST_C_3
GST_C_4
GST_N_3
HyaE HyaE
KaiB KaiB
NADH_4Fe-4S 2Fe-2S_thioredx
PAPS_reduct Thioredoxin
Phosducin Phosducin
Pyr_redox Thioredoxin
Pyr_redox_2 Thioredoxin
Redoxin DsbC
Glutaredoxin
Redoxin
Thioredoxin
SCO1-SenC SCO1-SenC
SH3BGR SH3BGR
SLBB 2Fe-2S_thioredx
Thioredoxin DnaJ
Evr1_Alr
Exo_endo_phos
Kunitz_legume
LMWPc
PMSR
RHD_DNA_bind
Thioredoxin
Thioredoxin_3
Thioredoxin_6
Thioredoxin_2 DsbC
Thioredoxin_2
Thioredoxin_3 Pyr_redox_2
Thioredoxin_3
Thioredoxin_4 Thioredoxin_4
Thioredoxin_5 Thioredoxin_5
Thioredoxin_6 Thioredoxin
Thioredoxin_6
Thioredoxin_7 DsbC
Thioredoxin_7
Thioredoxin_8 Thioredoxin_8
Tubulin Thioredoxin
WD40 Phosducin
Zincin_1 Zincin_1

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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