This is families that have a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins .
This clan contains 7 families and the total number of domains in the clan is 53710. The clan was built by RD Finn.
- Honda M, Inoue J, Yoshimasu M, Ito Y, Shibata T, Mikawa T;, J Biol Chem. 2006;281:18549-18559.: Identification of the RecR Toprim domain as the binding site for both RecF and RecO. A role of RecR in RecFOR assembly at double-stranded DNA-single-stranded DNA junctions. PUBMED:16675461 EPMC:16675461
This clan contains the following 7 member families:DUF2220 DUF2399 DUF3854 Toprim Toprim_2 Toprim_3 Toprim_4
External database links
Below is a listing of the unique domain organisations or architectures from this clan. More...
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
- the Pfam graphic itself.
in each row.
Loading domain graphics...
|Pfam family||Num. domains||Alignment|
|Toprim (PF01751)||30193 (56.2%)||View|
|Toprim_4 (PF13662)||13369 (24.9%)||View|
|Toprim_2 (PF13155)||6260 (11.7%)||View|
|Toprim_3 (PF13362)||2030 (3.8%)||View|
|DUF2220 (PF09983)||900 (1.7%)||View|
|DUF2399 (PF09664)||515 (1.0%)||View|
|DUF3854 (PF12965)||443 (0.8%)||View|
|Total: 7||Total: 53710||Clan alignment|
This diagram shows the relationships between members of this clan. More...
This tree shows the occurrence of the domains in this clan across different species. More...
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There are 14 interactions for this clan. More...
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