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22  structures 673  species 1  interaction 11682  sequences 126  architectures

Clan: Transporter (CL0375)

Summary

Transporter superfamily, four TM region Add an annotation

The members of this superfamily are probably all transporter protein domains. All families normally carry four tansmembrane regions, which in many instances associate into hexameric structures. They are frequently involved in gap-junction formation between cells or in forming pores linking the cytosol with the extracellulare space 1,2]. The clan includes members of the TCDB superfamilies 1.A.24 and 1.A.25.

This clan contains 12 families and the total number of domains in the clan is 11682. The clan was built by A Bateman.

Literature references

  1. Hua VB, Chang AB, Tchieu JH, Kumar NM, Nielsen PA, Saier MH Jr;, J Membr Biol. 2003;194:59-76.: Sequence and phylogenetic analyses of 4 TMS junctional proteins of animals: connexins, innexins, claudins and occludins. PUBMED:14502443 EPMC:14502443
  2. Abascal F, Zardoya R;, Bioessays. 2012;34:551-560.: LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell-cell communication. PUBMED:22532330 EPMC:22532330

Members

This clan contains the following 12 member families:

Amastin Claudin_2 Claudin_3 Clc-like Connexin Fig1 GSG-1 Innexin L_HGMIC_fpl Pannexin_like PMP22_Claudin SUR7

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PMP22_Claudin (PF00822) 3158 (27.0%) View
Connexin (PF00029) 1881 (16.1%) View
SUR7 (PF06687) 1612 (13.8%) View
Innexin (PF00876) 1505 (12.9%) View
Claudin_2 (PF13903) 1124 (9.6%) View
L_HGMIC_fpl (PF10242) 720 (6.2%) View
Amastin (PF07344) 503 (4.3%) View
Pannexin_like (PF12534) 393 (3.4%) View
Fig1 (PF12351) 306 (2.6%) View
GSG-1 (PF07803) 211 (1.8%) View
Clc-like (PF07062) 142 (1.2%) View
Claudin_3 (PF06653) 127 (1.1%) View
Total: 12 Total: 11682 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There is 1 interaction for this clan. More...

Interacting families
A B
Connexin Connexin

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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