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1097  structures 17585  species 27  interactions 151735  sequences 1812  architectures

Clan: Transthyretin (CL0287)


Transthyretin superfamily Add an annotation

This clan unifies several SCOP superfamilies that all share a 7 stranded beta sandwich fold.

This clan contains 18 families and the total number of domains in the clan is 151735. The clan was built by A Bateman.


This clan contains the following 18 member families:

Antigen_C CarbopepD_reg_2 CarboxypepD_reg Cna_B Dioxygenase_C DUF1416 DUF2012 DUF2606 DUF3823 DUF3869 FctA fn3_3 GramPos_pilinBB GramPos_pilinD3 PEGA phage_tail_N Transthyretin TTR-52

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Cna_B (PF05738) 72825 (48.0%) View
CarbopepD_reg_2 (PF13715) 30905 (20.4%) View
CarboxypepD_reg (PF13620) 9847 (6.5%) View
Dioxygenase_C (PF00775) 9194 (6.1%) View
Transthyretin (PF00576) 7116 (4.7%) View
Antigen_C (PF16364) 4184 (2.8%) View
phage_tail_N (PF08400) 4100 (2.7%) View
FctA (PF12892) 3187 (2.1%) View
PEGA (PF08308) 2847 (1.9%) View
DUF1416 (PF07210) 2339 (1.5%) View
GramPos_pilinBB (PF16569) 1964 (1.3%) View
TTR-52 (PF01060) 837 (0.6%) View
fn3_3 (PF14686) 743 (0.5%) View
DUF2012 (PF09430) 586 (0.4%) View
GramPos_pilinD3 (PF16570) 541 (0.4%) View
DUF3823 (PF12866) 277 (0.2%) View
DUF3869 (PF12985) 137 (0.1%) View
DUF2606 (PF10794) 106 (0.1%) View
Total: 18 Total: 151735 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 27 interactions for this clan. More...

Interacting families
CarboxypepD_reg CarboxypepD_reg
Cna_B Cna_B
Cohesin CarboxypepD_reg
Dioxygenase_C Dioxygenase_C
Dioxygenase_N Dioxygenase_C
DUF3823 DUF3823
DUF3869 DUF3870
Fb_signal Cna_B
FctA FctA
Fer4_11 Cna_B
fn3_3 CBM-like
Fn_bind Cna_B
Molybdopterin Cna_B
PCDO_beta_N Dioxygenase_C
Peptidase_M14 CarboxypepD_reg
RhgB_N fn3_3
Transthyretin Lipocalin


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...