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616  structures 5068  species 13  interactions 15511  sequences 193  architectures

Clan: Tubulin (CL0566)

Summary

Tubulin nucleotide-binding domain-like, GTPase Add an annotation

The characteristic families of this clan are the tubulin GTPase domain and the alpha and beta tubulin subunits. A segmental duplication early on in the primate lineage has led to the creation of up to three tubulin-like domains in the higher primates. The most N-terminal one is the Misato domain, which probably represents the original domain [3].

This clan contains 4 families and the total number of domains in the clan is 15511. The clan was built by P Coggill.

Literature references

  1. Nogales E, Downing KH, Amos LA, Lowe J; , Nat Struct Biol 1998;5:451-458.: Tubulin and FtsZ form a distinct family of GTPases. PUBMED:9628483 EPMC:9628483
  2. Dyer N;, Sci Prog. 2009;92:113-137.: Tubulin and its prokaryotic homologue FtsZ: a structural and functional comparison. PUBMED:19697711 EPMC:19697711
  3. Kuryshev VY, Vorobyov E, Zink D, Schmitz J, Rozhdestvensky TS, Munstermann E, Ernst U, Wellenreuther R, Moosmayer P, Bechtel S, Schupp I, Horst J, Korn B, Poustka A, Wiemann S;, Genomics. 2006;88:143-151.: An anthropoid-specific segmental duplication on human chromosome 1q22. PUBMED:16545939 EPMC:16545939

Members

This clan contains the following 4 member families:

Misat_Tub_SegII Tubulin Tubulin_2 Tubulin_3

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Tubulin (PF00091) 13920 (89.7%) View
Tubulin_3 (PF14881) 680 (4.4%) View
Misat_Tub_SegII (PF10644) 630 (4.1%) View
Tubulin_2 (PF13809) 281 (1.8%) View
Total: 4 Total: 15511 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 13 interactions for this clan. More...

Interacting families
A B
FtsZ_C Tubulin
Kinesin Tubulin
MT Tubulin
Tubulin Ank_2
CH
DCX
FtsZ_C
Kinesin
Stathmin
Thioredoxin
Tubulin
Tubulin_C
Tubulin_C Tubulin

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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