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28  structures 7970  species 2  interactions 15733  sequences 35  architectures

Clan: UB2H (CL0664)

Summary

UB2H/UvrB interaction domain superfamily Add an annotation

This superfamily includes the UB2H domain and a domain from the UvrB protein. This domain is also found in the Mfd protein [2].

This clan contains 2 families and the total number of domains in the clan is 15733. The clan was built by A Bateman.

Literature references

  1. Markovski M, Bohrhunter JL, Lupoli TJ, Uehara T, Walker S, Kahne DE, Bernhardt TG;, Proc Natl Acad Sci U S A. 2016;113:4788-4793.: Cofactor bypass variants reveal a conformational control mechanism governing cell wall polymerase activity. PUBMED:27071112 EPMC:27071112
  2. Assenmacher N, Wenig K, Lammens A, Hopfner KP;, J Mol Biol. 2006;355:675-683.: Structural basis for transcription-coupled repair: the N terminus of Mfd resembles UvrB with degenerate ATPase motifs. PUBMED:16309703 EPMC:16309703

Members

This clan contains the following 2 member families:

UB2H UvrB_inter

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
UvrB_inter (PF17757) 14839 (94.3%) View
UB2H (PF14814) 894 (5.7%) View
Total: 2 Total: 15733 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 2 interactions for this clan. More...

Interacting families
A B
UB2H Transgly
Transpeptidase

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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