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28  structures 7970  species 2  interactions 15733  sequences 35  architectures

Clan: UB2H (CL0664)


UB2H/UvrB interaction domain superfamily Add an annotation

This superfamily includes the UB2H domain and a domain from the UvrB protein. This domain is also found in the Mfd protein [2].

This clan contains 2 families and the total number of domains in the clan is 15733. The clan was built by A Bateman.

Literature references

  1. Markovski M, Bohrhunter JL, Lupoli TJ, Uehara T, Walker S, Kahne DE, Bernhardt TG;, Proc Natl Acad Sci U S A. 2016;113:4788-4793.: Cofactor bypass variants reveal a conformational control mechanism governing cell wall polymerase activity. PUBMED:27071112 EPMC:27071112
  2. Assenmacher N, Wenig K, Lammens A, Hopfner KP;, J Mol Biol. 2006;355:675-683.: Structural basis for transcription-coupled repair: the N terminus of Mfd resembles UvrB with degenerate ATPase motifs. PUBMED:16309703 EPMC:16309703


This clan contains the following 2 member families:

UB2H UvrB_inter

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
UvrB_inter (PF17757) 14839 (94.3%) View
UB2H (PF14814) 894 (5.7%) View
Total: 2 Total: 15733 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 2 interactions for this clan. More...

Interacting families
UB2H Transgly


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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