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310  structures 7  species 11  interactions 9  sequences 3  architectures

Clan: Viral_gly_cn_dm (CL0543)


Viral glycoprotein central and dimerisation domains Add an annotation

Flavivirus and alpha virus glycoprotein E/E1 consists of three domains. A dimerisation domain, a central domain and an immunoglobulin-like domain. The dimerisation and central domains are intertwined [1-3].

This clan contains 2 families and the total number of domains in the clan is 9. The clan was built by R Eberhardt.

Literature references

  1. Ferlenghi I, Clarke M, Ruttan T, Allison SL, Schalich J, Heinz FX, Harrison SC, Rey FA, Fuller SD;, Mol Cell. 2001;7:593-602.: Molecular organization of a recombinant subviral particle from tick-borne encephalitis virus. PUBMED:11463384 EPMC:11463384
  2. Lescar J, Roussel A, Wien MW, Navaza J, Fuller SD, Wengler G, Wengler G, Rey FA;, Cell. 2001;105:137-148.: The Fusion glycoprotein shell of Semliki Forest virus: an icosahedral assembly primed for fusogenic activation at endosomal pH. PUBMED:11301009 EPMC:11301009
  3. Modis Y, Ogata S, Clements D, Harrison SC;, Proc Natl Acad Sci U S A. 2003;100:6986-6991.: A ligand-binding pocket in the dengue virus envelope glycoprotein. PUBMED:12759475 EPMC:12759475


This clan contains the following 2 member families:

Alpha_E1_glycop Flavi_glycoprot

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Alpha_E1_glycop (PF01589) 5 (55.6%) View
Flavi_glycoprot (PF00869) 4 (44.4%) View
Total: 2 Total: 9 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 11 interactions for this clan. More...

Interacting families
Alpha_E1_glycop Alpha_E1_glycop
Alpha_E2_glycop Alpha_E1_glycop
Flavi_glycop_C Flavi_glycoprot
Flavi_glycoprot Flavi_glycop_C
Peptidase_S3 Alpha_E1_glycop


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...