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0  structures 2880  species 0  interactions 8038  sequences 52  architectures

Clan: WYL (CL0654)

Summary

WYL-like superfamily Add an annotation

Members of this clan all belong to the WYL-like superfamily, and show structural similarity to the Sm-like SH3 beta-barrel fold. The WYL domain was first named for three conserved amino acids, however this motif was subsequently shown to be found only in a small subset of examples of this clan. The conservation pattern more widely applicable across the clan includes four basic residues and a position often occupied by a cysteine. These residues are predicted to line a ligand-binding groove similar to that found in Sm-like SH3 beta-barrels. WYL domains often occur in two copies in the same protein, or are encoded alongside neighbouring genes that encode multi-WYL domain proteins, and it has been suggested that they form toroidal multimeric assemblies. WYL domains are often associated with various predicted DNA-binding N-terminal wHTH domains, but may also exist as fusions to several enzymatic domains.

This clan contains 3 families and the total number of domains in the clan is 8038. The clan was built by L Richardson.

Literature references

  1. Makarova KS, Anantharaman V, Grishin NV, Koonin EV, Aravind L;, Front Genet. 2014;5:102.: CARF and WYL domains: ligand-binding regulators of prokaryotic defense systems. PUBMED:24817877 EPMC:24817877

Members

This clan contains the following 3 member families:

WYL WYL_2 YolD

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
WYL (PF13280) 7522 (93.6%) View
YolD (PF08863) 438 (5.4%) View
WYL_2 (PF10902) 78 (1.0%) View
Total: 3 Total: 8038 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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