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2  structures 5504  species 0  interactions 16257  sequences 70  architectures

Clan: WYL (CL0654)


WYL-like superfamily Add an annotation

Members of this clan all belong to the WYL-like superfamily, and show structural similarity to the Sm-like SH3 beta-barrel fold. The WYL domain was first named for three conserved amino acids, however this motif was subsequently shown to be found only in a small subset of examples of this clan. The conservation pattern more widely applicable across the clan includes four basic residues and a position often occupied by a cysteine. These residues are predicted to line a ligand-binding groove similar to that found in Sm-like SH3 beta-barrels. WYL domains often occur in two copies in the same protein, or are encoded alongside neighbouring genes that encode multi-WYL domain proteins, and it has been suggested that they form toroidal multimeric assemblies. WYL domains are often associated with various predicted DNA-binding N-terminal wHTH domains, but may also exist as fusions to several enzymatic domains.

This clan contains 4 families and the total number of domains in the clan is 16257. The clan was built by L Richardson.

Literature references

  1. Makarova KS, Anantharaman V, Grishin NV, Koonin EV, Aravind L;, Front Genet. 2014;5:102.: CARF and WYL domains: ligand-binding regulators of prokaryotic defense systems. PUBMED:24817877 EPMC:24817877


This clan contains the following 4 member families:


Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
WYL (PF13280) 15198 (93.5%) View
YolD (PF08863) 849 (5.2%) View
WYL_2 (PF10902) 166 (1.0%) View
WYL_3 (PF18488) 44 (0.3%) View
Total: 4 Total: 16257 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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