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0  structures 247  species 0  interactions 297  sequences 15  architectures

Clan: aG_PT (CL0686)


Alpha-glutamyl/putrescinyl thymine phosphorylase Add an annotation

This clan includes alpha-glutamyl/putrescinyl thymine phosphorylase related entries. According to sequence analysis several clades have been identified such as Clade-1, a prototypical aG/PT-pyrophoshorylase and Clade-2 pyrophoshorylases which are mainly found mainly in caudoviruses and prophages, where they are usually linked to a P-loop kinase. Several phages possess both a clade-1 aG/PT-pyrophoshorylase domain and a clade-2 protein [1].

This clan contains 3 families and the total number of domains in the clan is 297. The clan was built by S El-Gebali.

Literature references

  1. Iyer LM, Zhang D, Burroughs AM, Aravind L;, Nucleic Acids Res. 2013;41:7635-7655.: Computational identification of novel biochemical systems involved in oxidation, glycosylation and other complex modifications of bases in DNA. PUBMED:23814188 EPMC:23814188


This clan contains the following 3 member families:

aGPT-Pplase1 aGPT-Pplase2 aGPT-Pplase3

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
aGPT-Pplase1 (PF18723) 237 (79.8%) View
aGPT-Pplase2 (PF18724) 39 (13.1%) View
aGPT-Pplase3 (PF18746) 21 (7.1%) View
Total: 3 Total: 297 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...