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116  structures 865  species 5  interactions 3296  sequences 59  architectures

Clan: eIF4e (CL0625)

Summary

eIF4e-like superfamily Add an annotation

This superfamily includes eIF4e as well as the family that includes BLES03 [1].

This clan contains 3 families and the total number of domains in the clan is 3296. The clan was built by A Bateman.

Literature references

  1. Bitto E, Bingman CA, Robinson H, Allard ST, Wesenberg GE, Phillips GN Jr;, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005;61:812-817.: The structure at 2.5 A resolution of human basophilic leukemia-expressed protein BLES03. PUBMED:16511166 EPMC:16511166

Members

This clan contains the following 3 member families:

DUF1917 IF4E VRP3

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
IF4E (PF01652) 2861 (86.8%) View
DUF1917 (PF08939) 419 (12.7%) View
VRP3 (PF03536) 16 (0.5%) View
Total: 3 Total: 3296 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 5 interactions for this clan. More...

Interacting families
A B
DUF1917 DUF1917
IF4E eIF_4EBP
eIF_4G1
IF4E
VRP3 VRP3

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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