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282  structures 306  species 16  interactions 4784  sequences 83  architectures

Clan: uPAR_Ly6_toxin (CL0117)


uPAR/Ly6/CD59/snake toxin-receptor superfamily Add an annotation

This superfamily contains snake toxins as well as extracellular cysteine rich domains.

This clan contains 7 families and the total number of domains in the clan is 4784. The clan was built by A Bateman.


This clan contains the following 7 member families:

Activin_recp BAMBI ecTbetaR2 PLA2_inh Toxin_TOLIP UPAR_LY6 UPAR_LY6_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
UPAR_LY6 (PF00021) 1872 (39.1%) View
Activin_recp (PF01064) 1768 (37.0%) View
UPAR_LY6_2 (PF16975) 322 (6.7%) View
Toxin_TOLIP (PF00087) 296 (6.2%) View
ecTbetaR2 (PF08917) 223 (4.7%) View
BAMBI (PF06211) 170 (3.6%) View
PLA2_inh (PF02988) 133 (2.8%) View
Total: 7 Total: 4784 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 16 interactions for this clan. More...

Interacting families
Activin_recp Activin_recp
COesterase Toxin_TOLIP
ecTbetaR2 Activin_recp
Kringle UPAR_LY6
Neur_chan_LBD Toxin_TOLIP
Somatomedin_B UPAR_LY6
TGF_beta Activin_recp
Thiol_cytolysin UPAR_LY6
Toxin_TOLIP Neur_chan_LBD
UPAR_LY6 Kringle
V-set UPAR_LY6


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...