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279  structures 14882  species 32  interactions 95028  sequences 2005  architectures

Clan: vWA-like (CL0128)

Summary

von Willebrand factor type A Add an annotation

To add.

This clan contains 16 families and the total number of domains in the clan is 95028. The clan was built by RD Finn.

Literature references

  1. Whittaker CA, Hynes RO; , Mol Biol Cell 2002;13:3369-3387.: Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere. PUBMED:12388743 EPMC:12388743

Members

This clan contains the following 16 member families:

CobT_C Copine DUF1194 DUF2201 DUF444 DUF58 Ku_N Med25_VWA Sec23_trunk Ssl1 Tfb4 VWA vWA-TerF-like VWA_2 VWA_3 VWA_CoxE

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
VWA_2 (PF13519) 27850 (29.3%) View
VWA (PF00092) 20053 (21.1%) View
DUF58 (PF01882) 14452 (15.2%) View
VWA_CoxE (PF05762) 12737 (13.4%) View
DUF444 (PF04285) 5893 (6.2%) View
Sec23_trunk (PF04811) 2941 (3.1%) View
Copine (PF07002) 2185 (2.3%) View
VWA_3 (PF13768) 2085 (2.2%) View
CobT_C (PF11775) 1705 (1.8%) View
Ku_N (PF03731) 1231 (1.3%) View
DUF2201 (PF09967) 1062 (1.1%) View
Ssl1 (PF04056) 716 (0.8%) View
vWA-TerF-like (PF10138) 709 (0.7%) View
Tfb4 (PF03850) 688 (0.7%) View
DUF1194 (PF06707) 472 (0.5%) View
Med25_VWA (PF11265) 249 (0.3%) View
Total: 16 Total: 95028 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 32 interactions for this clan. More...

Interacting families
A B
A2M_comp VWA
Anth_Ig VWA
Binary_toxB VWA
Gelsolin Sec23_trunk
ICAM_N VWA
JAB VWA_2
Ku Ku_N
Ku_N Ku
Ku_C
Lectin_C VWA
NTR VWA
SAP Ku_N
Sec23_trunk Arf
Gelsolin
Longin
Sec23_BS
Sec23_helical
Sec23_trunk
Sec31
Sushi VWA
VWA Anth_Ig
CompInhib_SCIN
ICAM_N
Integrin_beta
Lectin_C
LRR_8
LRRNT
Mg_chelatase
Trypsin
V-set
VWA
VWA_2 VWA_2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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