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203  structures 1791  species 12  interactions 34206  sequences 1521  architectures

Clan: zf-FYVE-PHD (CL0390)

Summary

FYVE/PHD zinc finger superfamily Add an annotation

Superfamily contains a number of zinc-fingers, of the FYVE/PHD type, which are found in several groups of proteins including myelin-associated oligodendrocytic basic proteins (MOBP) Rabphilins, melanophilins, exophilins and myosin-VIIA and Rab-interacting protein families.

This clan contains 10 families and the total number of domains in the clan is 34206. The clan was built by P Coggill.

Members

This clan contains the following 10 member families:

FYVE FYVE_2 PHD PHD_2 PHD_Oberon RAG2_PHD zf-HC5HC2H zf-HC5HC2H_2 zf-PHD-like zf-piccolo

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PHD (PF00628) 14670 (42.9%) View
FYVE (PF01363) 8998 (26.3%) View
zf-HC5HC2H_2 (PF13832) 3124 (9.1%) View
PHD_2 (PF13831) 2364 (6.9%) View
zf-HC5HC2H (PF13771) 1757 (5.1%) View
RAG2_PHD (PF13341) 1260 (3.7%) View
FYVE_2 (PF02318) 1076 (3.1%) View
PHD_Oberon (PF07227) 484 (1.4%) View
zf-piccolo (PF05715) 295 (0.9%) View
zf-PHD-like (PF15446) 178 (0.5%) View
Total: 10 Total: 34206 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 12 interactions for this clan. More...

Interacting families
A B
Bromodomain PHD
C2 FYVE_2
FYVE FYVE
FYVE_2 FYVE_2
Ras
PHD Bromodomain
JmjC
PHD
RRM_1
RAG2_PHD RAG2_PHD
Ras FYVE_2
VHS FYVE

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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