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216  structures 8200  species 0  interactions 36574  sequences 3156  architectures

Family: Acyl_transf_1 (PF00698)

Summary: Acyl transferase domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Acyl transferase domain Provide feedback

No Pfam abstract.

Literature references

  1. Serre L, Verbree EC, Dauter Z, Stuitje AR, Derewenda ZS; , J Biol Chem 1995;270:12961-12964.: The Escherichia coli malonyl-CoA:acyl carrier protein transacylase at 1.5-A resolution. Crystal structure of a fatty acid synthase component. PUBMED:7768883 EPMC:7768883


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR014043

Enzymes like bacterial malonyl CoA-acly carrier protein transacylase ( EC ) and eukaryotic fatty acid synthase ( EC ) that are involved in fatty acid biosynthesis belong to this group. Also included are the polyketide synthases 6-methylsalicylic acid synthase ( EC ), a multifunctional enzyme that involved in the biosynthesis of patulin and conidial green pigment synthase ( EC ) and several non-reducing polyketide synthases.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Patatin (CL0323), which has the following description:

This superfamily of enzymes contains a Ser/Asp catalytic dyad. Members of this superfamily are all serine acylhydrolase enzymes.

The clan contains the following 4 members:

Acyl_transf_1 Patatin PLA2_B SAT

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(8)
Full
(36574)
Representative proteomes UniProt
(130288)
RP15
(3507)
RP35
(14850)
RP55
(34127)
RP75
(59434)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(8)
Full
(36574)
Representative proteomes UniProt
(130288)
RP15
(3507)
RP35
(14850)
RP55
(34127)
RP75
(59434)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(8)
Full
(36574)
Representative proteomes UniProt
(130288)
RP15
(3507)
RP35
(14850)
RP55
(34127)
RP75
(59434)
Raw Stockholm Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_250 (release 2.1)
Previous IDs: Acyl_transf;
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A
Number in seed: 8
Number in full: 36574
Average length of the domain: 298.70 aa
Average identity of full alignment: 26 %
Average coverage of the sequence by the domain: 19.45 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 32.7 32.7
Trusted cut-off 32.7 32.7
Noise cut-off 32.6 32.6
Model length: 319
Family (HMM) version: 24
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Acyl_transf_1 domain has been found. There are 216 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A089QRB9 View 3D Structure Click here
A0A1D8PT17 View 3D Structure Click here
A4IBN7 View 3D Structure Click here
B0G100 View 3D Structure Click here
B0G101 View 3D Structure Click here
B0G103 View 3D Structure Click here
B0G170 View 3D Structure Click here
B6TNM0 View 3D Structure Click here
B7Z001 View 3D Structure Click here
D3ZPF2 View 3D Structure Click here
E7F5V3 View 3D Structure Click here
I1LLS4 View 3D Structure Click here
I1MZV4 View 3D Structure Click here
I6X8D2 View 3D Structure Click here
I6Y231 View 3D Structure Click here
M9PB21 View 3D Structure Click here
O06586 View 3D Structure Click here
O13698 View 3D Structure Click here
O53901 View 3D Structure Click here
O65933 View 3D Structure Click here
O86335 View 3D Structure Click here
P07149 View 3D Structure Click here
P0AAI9 View 3D Structure Click here
P12785 View 3D Structure Click here
P19096 View 3D Structure Click here
P49327 View 3D Structure Click here
P71719 View 3D Structure Click here
P91871 View 3D Structure Click here
P94996 View 3D Structure Click here
P96202 View 3D Structure Click here
P96285 View 3D Structure Click here
P9WNG5 View 3D Structure Click here
P9WQE1 View 3D Structure Click here
P9WQE3 View 3D Structure Click here
P9WQE5 View 3D Structure Click here
P9WQE7 View 3D Structure Click here
P9WQE9 View 3D Structure Click here
Q10MS3 View 3D Structure Click here
Q2FZ54 View 3D Structure Click here
Q4D2Q5 View 3D Structure Click here