Summary: Apolipophorin-III precursor (apoLp-III)
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This is the Wikipedia entry entitled "Apolipophorin III". More...
Apolipophorin III Edit Wikipedia article
ApoLp-III | |||||||||
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![]() nmr structure of an exchangeable apolipoprotein-manduca sexta apolipophorin-iii | |||||||||
Identifiers | |||||||||
Symbol | ApoLp-III | ||||||||
Pfam | PF07464 | ||||||||
InterPro | IPR010009 | ||||||||
SCOPe | 1eq1 / SUPFAM | ||||||||
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In molecular biology, the apolipophorin III family of proteins are a family of exchangeable apolipoproteins. Exchangeable apolipoproteins constitute a functionally important family of proteins that play critical roles in lipid transport and lipoprotein metabolism. Apolipophorin III (apoLp-III) is a prototypical exchangeable apolipoprotein found in many insect species that functions in transport of diacylglycerol (DAG) from the fat body lipid storage depot to flight muscles in the adult life stage.[1]
References
- ^ Wang J, Sykes BD, Ryan RO (February 2002). "Structural basis for the conformational adaptability of apolipophorin III, a helix-bundle exchangeable apolipoprotein". Proc. Natl. Acad. Sci. U.S.A. 99 (3): 1188–93. doi:10.1073/pnas.032565999. PMC 122165. PMID 11818551.
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This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.
Apolipophorin-III precursor (apoLp-III) Provide feedback
This family consists of several insect apolipoprotein-III sequences. Exchangeable apolipoproteins constitute a functionally important family of proteins that play critical roles in lipid transport and lipoprotein metabolism. Apolipophorin III (apoLp-III) is a prototypical exchangeable apolipoprotein found in many insect species that functions in transport of diacylglycerol (DAG) from the fat body lipid storage depot to flight muscles in the adult life stage [1].
Literature references
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Wang J, Sykes BD, Ryan RO; , Proc Natl Acad Sci U S A 2002;99:1188-1193.: Structural basis for the conformational adaptability of apolipophorin III, a helix-bundle exchangeable apolipoprotein. PUBMED:11818551 EPMC:11818551
Internal database links
SCOOP: | AAA_13 Apolipoprotein Baculo_PEP_C DUF1640 DUF1664 DUF4455 DUF883 DUF948 Exonuc_VII_L Fib_alpha Gp58 MCPsignal Prominin Spc7 YtxH |
External database links
SCOP: | 1eq1 |
This tab holds annotation information from the InterPro database.
InterPro entry IPR010009
This family consists of several insect apolipoprotein-III sequences. Exchangeable apolipoproteins constitute a functionally important family of proteins that play critical roles in lipid transport and lipoprotein metabolism. Apolipophorin III (apoLp-III) is a prototypical exchangeable apolipoprotein found in many insect species that functions in transport of diacylglycerol (DAG) from the fat body lipid storage depot to flight muscles in the adult life stage [PUBMED:11818551].
Gene Ontology
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
Cellular component | extracellular region (GO:0005576) |
Molecular function | lipid binding (GO:0008289) |
Biological process | lipid transport (GO:0006869) |
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
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Alignments
We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...
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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
Seed (12) |
Full (68) |
Representative proteomes | UniProt (178) |
NCBI (177) |
Meta (0) |
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RP15 (13) |
RP35 (33) |
RP55 (54) |
RP75 (69) |
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PP/heatmap | 1 |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
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Seed (12) |
Full (68) |
Representative proteomes | UniProt (178) |
NCBI (177) |
Meta (0) |
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RP15 (13) |
RP35 (33) |
RP55 (54) |
RP75 (69) |
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Raw Stockholm | |||||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
Trees
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
Curation
Seed source: | Pfam-B_31170 (release 10.0) |
Previous IDs: | none |
Type: | Family |
Sequence Ontology: | SO:0100021 |
Author: |
Moxon SJ |
Number in seed: | 12 |
Number in full: | 68 |
Average length of the domain: | 140.80 aa |
Average identity of full alignment: | 27 % |
Average coverage of the sequence by the domain: | 60.79 % |
HMM information
HMM build commands: |
build method: hmmbuild --amino -o /dev/null HMM SEED
search method: hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
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Model details: |
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Model length: | 146 | ||||||||||||
Family (HMM) version: | 12 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the ApoLp-III domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.
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