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83  structures 1421  species 10  interactions 1691  sequences 8  architectures

Family: Cytochrom_C1 (PF02167)

Summary: Cytochrome C1 family

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This is the Wikipedia entry entitled "Cytochrome C1". More...

Cytochrome C1 Edit Wikipedia article

Cytochrom_C1
PDB 1l0n EBI.jpg
native structure of bovine mitochondrial cytochrome bc1 complex
Identifiers
Symbol Cytochrom_C1
Pfam PF02167
Pfam clan CL0318
InterPro IPR002326
SCOP 3bcc
SUPERFAMILY 3bcc
TCDB 3.D.3

Cytochrome C1 is formed in the cytosol and targeted to the mitochondrial intermembrane space. It is one of the constituents of complex III, which forms the third proton pump in the mitochondrial electron transport chain.

Cytochrome c1 is a subunit of the electron transport chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, UQCRQ [1]("11kDa protein"), UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and UQCR [2]("Rieske-associated protein").

Ubiquinol:ferricytochrome c oxidoreductase is found in mitochondria, photosynthetic bacteria and other prokaryotes. The general function of the complex is electron transfer between two mobile redox carriers, ubiquinol and cytochrome c; the electron transfer is coupled with proton translocation across the membrane, thus generating proton-motive force in the form of an electrochemical potential difference that can drive ATP synthesis. In its structure and functions, the cytochrome bc1 complex bears extensive analogy to the cytochrome b6f complex of chloroplasts and cyanobacteria; cyt c1 plays an analogous role to cytochrome f, in spite of their different structures.[1]


External links

References

  1. ^ Prince RC, George GN (June 1995). "Cytochrome f revealed". Trends Biochem. Sci. 20 (6): 217–8. PMID 7631417. 

This article incorporates text from the public domain Pfam and InterPro IPR002326

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

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Cytochrome C1 family Provide feedback

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Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR002326

Cytochrome bc1 complex (ubiquinol:ferricytochrome c oxidoreductase) is found in mitochondria, photosynthetic bacteria and other prokaryotes. It is minimally composed of three subunits: cytochrome b, carrying a low- and a high-potential haem group; cytochrome c1 (cyt c1); and a high-potential Rieske iron-sulphur protein. The general function of the complex is electron transfer between two mobile redox carriers, ubiquinol and cytochrome c; the electron transfer is coupled with proton translocation across the membrane, thus generating proton-motive force in the form of an electrochemical potential that can drive ATP synthesis. In its structure and functions, the cytochrome bc1 complex bears extensive analogy to the cytochrome b6f complex of chloroplasts and cyanobacteria; cyt c1 plays an analogous role to cytochrome f, in spite of their different structures [PUBMED:7631417].

Gene Ontology

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Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Cytochrome-c (CL0318), which has the following description:

This family includes proteins where a covalently-bound haem completes the core. The core is three helices in an open folded leaf formation. The members are monodomain cytochromes.

The clan contains the following 10 members:

CCP_MauG Cytochrom_C Cytochrom_C1 Cytochrom_C550 Cytochrome_CBB3 Dehyd-heme_bind DUF1111 DUF1924 FixO PSCyt1

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the NCBI sequence database, and our metagenomics sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(124)
Full
(1691)
Representative proteomes NCBI
(1376)
Meta
(2156)
RP15
(173)
RP35
(330)
RP55
(465)
RP75
(579)
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  Seed
(124)
Full
(1691)
Representative proteomes NCBI
(1376)
Meta
(2156)
RP15
(173)
RP35
(330)
RP55
(465)
RP75
(579)
Alignment:
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Sequence:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(124)
Full
(1691)
Representative proteomes NCBI
(1376)
Meta
(2156)
RP15
(173)
RP35
(330)
RP55
(465)
RP75
(579)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

External links

MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: IPR002326
Previous IDs: Cytochrome_C1;
Type: Family
Author: Mian N, Bateman A
Number in seed: 124
Number in full: 1691
Average length of the domain: 190.90 aa
Average identity of full alignment: 30 %
Average coverage of the sequence by the domain: 70.78 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 20.2 20.2
Trusted cut-off 20.2 20.2
Noise cut-off 20.1 20.1
Model length: 219
Family (HMM) version: 10
Download: download the raw HMM for this family

Species distribution

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Interactions

There are 10 interactions for this family. More...

UCR_UQCRX_QCR9 UCR_hinge UCR_14kD Rieske UCR_Fe-S_N UcrQ Cytochrom_B_N Cytochrom_C1 UCR_TM Cytochrom_B_C

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Cytochrom_C1 domain has been found. There are 83 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.

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